Researchers in University of Warwickshire develop 2D mass spectrometry using Linear ion trap.

Professor Peter O’Connor and Dr Maria van Agthoven in the Department of Chemistry have invented a device which makes 2D mass spectrometry – an effective process for analysing and sequencing proteins. This could enable researchers and companies to produce data-driven results on how protein molecules function, more easily and cheaply. 2D mass spectrometry allows chemists to explore the elemental composition and structure of a molecule by breaking it apart, and analysing its fragmented pieces – measuring mass, and gathering data on how the whole molecule functions and interacts with its environment.

High numbers of molecules can be experimented on at the same time in this way, as the various fragments of different broken molecules can be modulated at the same frequencies as the molecule from which they originated. Professor O’Connor and Dr van Agthoven have patented an instrument with which 2D Mass spectrometry can be performed using a linear ion trap – this is a cheaper, smaller, and much more accessible option than was previously available. The device can be added onto existing MS instruments as well as being bought with new instruments.

Mass spectrometry produces precise results during protein sequencing, and this type of data-driven biology will produce quicker, better results than are currently obtained in pharmaceutical and biomedical research.

Dr van Agthoven comments that the breakthrough could have numerous and varied applications: “Two-dimensional mass spectrometry has the potential to exponentially increase our knowledge in all areas, from biochemistry to food safety and environmental chemistry.” Professor O’Connor is confident that this invention will change biomedical research dramatically: “2-Dimensional mass spectrometry in a simple and cheap linear ion trap will revolutionise proteomics and detailed characterisation of complex samples.”

Press release: Breakthrough in analytical sciences could lead to medical revolution