Researchers developed a predictive model for quantitative prediction and evaluation of the risk of gestational hypertension (GH) evolving into pre-eclampsia (PE) complicated with HELLP syndrome. HELLP syndrome represents a serious complication in hypertensive disorders during pregnancy, leading to rapid organ dysfunction and increased risk of maternal death.
A retrospective case-control study was conducted on 465 patients with GH and PE complicated with HELLP syndrome. The study identified several factors, such as blood pressure metrics, liver function tests, and blood coagulation indicators, that influence the progression to PE with HELLP syndrome through logistic regression analyses and the evaluation of ROC curves.
Based on these findings, researchers developed a predictive model. This model incorporated independent factors like mean arterial pressure (MAP), aspartate-aminotransferase to platelet ratio index (APRI), cholinesterase (CHE), fibrinogen degradation products (FDP), and calcium (Ca).
The model allows for quantitative prediction and evaluation of the risk of GH evolving into PE complicated with HELLP syndrome. Thus, it enhances the ability for early detection and intervention, potentially improving outcomes for pregnant women at risk of this severe complication.
Ref: Li Z, Dai Y, Yun L, Guo W. A prediction model for the progression from gestational hypertension to pre-eclampsia complicated with HELLP syndrome. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. Published online November 28, 2023. doi:10.1002/ijgo.15274
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