Category: Uncategorized
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Gene therapy for Cystic fibrosis updates
Two new studies from the University of Iowa suggest that gene therapy may be a viable approach for treating or preventing lung disease caused by cystic fibrosis (CF). Working with CF pigs, the researchers, based in the UI Pappajohn Biomedical Institute (PBI), have shown that two different virus-based vectors can restore a working version of…
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Universal biomarker to detect aging cell
(Manchester, UK) Scientists have discovered a new way to look for ageing cells across a wide range of biological materials; the new method will boost understanding of cellular development and ageing as well as the causes of diverse diseases. Cellular senescence is a fundamental biological process involved in every day embryonic and adult life, both…
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Research shows subopitmal reporting of adverse events in targeted therapy and immunotherapy trials
A significant number of trials of targeted therapies and immunotherapies in recent years show suboptimal reporting of adverse events, particularly the reporting of recurrent or late toxicities and the duration of the adverse events, researchers have told the ESMO 2016 Congress in Copenhagen. “Reporting adverse events from clinical trials with new agents is a crucial…
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Uncovering antibiotic resistance in Pseudomonas aeruginosa
Pseudomonas aeruginosa is a common bacterium of our environment. It can however become a formidable pathogen causing fatal infections, especially in intubated patients, people suffering from cystic fibrosis or severe burns. The presence of certain metals in the natural or human environment of the bacterium makes it more dangerous and, in particular, resistant to antibiotics…
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New Imaging technique to detect Chromatin in the cell (Partial Wave Spectroscopic Microscopy)
When scientists finished decoding the human genome in 2003, they thought the findings would help us better understand diseases, discover genetic mutations linked to cancer, and lead to the design of smarter medicine. Now it’s 13 years later, and not all of these ideas have not yet come to fruition. It turns out that genes…
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Human apoptosome structure determined and model recreated
Programmed cell death, or apoptosis, plays a central role in the maintenance of human health by providing a line of defense against unrestricted cell growth that occurs in many cancers and AIDS as well as in neurodegenerative diseases and stroke.Researchers from Boston University School of Medicine (BUSM) have for the first time mapped an active…
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University of Texas researchers developing radiotherapeutic gold nanoseeds to fight inoperable tumors
Many solid tumors are considered inoperable because they adhere to vital structures or the surgery would cause irreversible damages to the patients. In order to prevent the tumor growth or provide complete tumor resolution without surgery, chemotherapy and radiation are currently in clinical practice. Since these tumors are already locally advanced or have begun to…
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Research shows tumor-targeted radiosensitization using antibody drug conjugates may redues toxicity and improve outcome
Many types of cancer become drug resistant, making them difficult to treat. Researchers with University of California San Diego School of Medicine and Moores Cancer Center have identified a strategy to selectively sensitize certain cancer cells to radiation therapy that may improve tumor control and reduce treatment-related side effects. In a paper published in Nature…
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Genetic targets in Colorectal Cancer: role of KRAS, MEK and TAK1 genes Identified.
Researchers from Boston University School of Medicine have discovered a possible strategy to treat colon cancers that are caused by the mutant KRAS gene, which is responsible for approximately half of all colon cancer cases. The findings, which appear online in the journal Molecular Cancer Research, may lead to better therapeutic agents to treat this…
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