Anti aging drugs focus – Rapamycin

New opinion article by Dr. Mikhail V. Blagosklonny about anti aging drug published in the journal Aging. Drug in focus is rapamycin, which functions by inhibiting mTOR pathway. Similar drugs include everolimus. Normally when over-activated by nutrients and insulin, mTOR acts via S6K to inhibit insulin signaling, thereby causing insulin resistance. The evidence in preclinical … Continue reading Anti aging drugs focus – Rapamycin

Calorie restricted diet promotes intestinal regeneration after injury

Dramatic calorie restriction have long been known to boost healthy lifespan and reduce the risk of heart attack, diabetes and other age-related conditions. In animal studies it is shown to extend life span in most animal species examined. Further research has shown that animals fed restricted-calorie diets are also better able to regenerate numerous tissues … Continue reading Calorie restricted diet promotes intestinal regeneration after injury

Roadmap to develop strategies for radioresistance to facilitate space exploration published

An international team of researchers from various academic institutions and NASA Ames Research Center have published a roadmap toward enhancing human radioresistance in the peer-reviewed journal Oncotarget. This is important as our interest in space exploration and colonization is increasing and therefore, research into methods of enhancing radioresistance to protect against the various forms of … Continue reading Roadmap to develop strategies for radioresistance to facilitate space exploration published

Delaying aging process by selective removal of senescent cells

A recent study, led by an international team of researchers confirms that targeted removal of senescent cells (SnCs), accumulated in many vertebrate tissues as we age, contribute significantly in delaying the onset of age-related pathologies.Credit: Baker et al., Nature This breakthrough research has been led by Dr. Chaekyu Kim and Dr. Ok Hee Jeon. In the … Continue reading Delaying aging process by selective removal of senescent cells

Research shows rise in global life expectancy by 2030

The study, led by scientists from Imperial College London in collaboration with the World Health Organization, analyzed long-term data on mortality and longevity trends to predict how life expectancy will change in 35 industrialized countries by 2030. Nations in the study included both high-income countries, such as the USA, Canada, UK, Germany, Australia, and emerging … Continue reading Research shows rise in global life expectancy by 2030

Calorie restriction and cellular aging process

Recent research published in Molecular & Cellular Proteomics offers one glimpse into how cutting calories impacts aging inside a cell. The researchers found that when ribosomes - the cell's protein makers - slow down, the aging process slows too. The decreased speed lowers production but gives ribosomes extra time to repair themselves. Repairing individual parts … Continue reading Calorie restriction and cellular aging process

Research shows musicians have faster reaction to sensory stimuli

According to a new study by Université de Montréal’s School of Speech-Language Pathology and Audiology, part of UdeM’s medical faculty learning to play musical instrument help elderly to react faster and to stay alerted. The study is published in journal Brain and Cognition.  The study shows that musicians have faster reaction times to sensory stimuli than … Continue reading Research shows musicians have faster reaction to sensory stimuli

Effects of telomeres length on stem cells

Ever since researchers connected the shortening of telomeres the protective structures on the ends of chromosomes to aging and disease, the race has been on to understand the factors that govern telomere length. Now, Scientists at the Salk Institute have found that a balance of elongation and trimming in stem cells results in telomeres that … Continue reading Effects of telomeres length on stem cells

Combating Aging by removing damaged mitochondrial DNA

Researchers from UCLA and Caltech have made discoveries that might help slow and potentially reverse the process of aging in cells. They generated new methods that allow identification of factors that selectively remove damaged mitochondrial DNA, which will affect the process of aging at the cellular level. Aging is, in part, due to changes in … Continue reading Combating Aging by removing damaged mitochondrial DNA

New tool to discover bio-markers for aging using In-silico Pathway Activation Network Decomposition Analysis (iPANDA)

Today the Biogerontology Research Foundation announced the international collaboration on signaling pathway perturbation-based transcriptomic biomarkers of aging. On November 16th scientists at the Biogerontology Research Foundation alongside collaborators from Insilico Medicine, Inc, the Johns Hopkins University, Albert Einstein College of Medicine, Boston University, Novartis, Nestle and BioTime Inc. announced the publication of their proof of … Continue reading New tool to discover bio-markers for aging using In-silico Pathway Activation Network Decomposition Analysis (iPANDA)