Alzheimer-Disease

Researchers identify role of protein TOM-1 in Alzheimer’s disease pathology

The scientists from the University of California Irvine discovered that reducing the amount of protein TOM-1 in Alzheimer’s rodent models increased pathology, which included increased inflammation, and exacerbated cognitive problems associated with the disease and restoring TOM-1 levels reversed those effects. This research is significant as it explores the molecular pathways underlying Alzheimer’s disease. It …

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New retinal biomarker for identifying early Alzheimer’s disease

Researchers at the Complutense University of Madrid (UCM) have identified changes in retinal layer thickness, inflammation or thinning in patients with mild Alzheimer’s disease. These changes are identified with non invasive assessment using optical coherence tomography may be an important biomarker for early diagnosis. Researchers observed that in some patients diagnosed with Alzheimer’s disease, the …

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Early diagnosis of Alzheimer’s disease using artificial intelligence

According to a study published in the journal of radiology, research shows that artificial intelligence (AI) technology predict the development of Alzheimer’s disease early. Early diagnosis of Alzheimer’s is important as treatments and interventions are more effective early in the course of the disease. However, early diagnosis has proven to be challenging. Research has linked the …

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Preventing Alzheimer’s dementia with Ibuprofen

Researchers suggest that daily intake of nonsteroidal anti-inflammatory drugs like over the counter ibuprofen could prevent the onset of Alzheimer’s disease. This research is led by Dr. Patrick McGeer and is published in the Journal of Alzheimer’s Disease. Alzheimer’s dementia affects those diagnosed and their family along with a significant financial burden on the society. …

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Potential treatment for Alzheimer’s dementia using cell therapy

Researchers from Gladstone Institute uncovered the therapeutic benefits of genetically improving interneurons with a voltage-gated sodium channel Nav1.1 and transplanting them into the brain of a mouse model of Alzheimer’s disease. This study is led by Jorge Palop, Ph.D., an assistant investigator at the Gladstone Institutes. The study findings are published in journal Neuron. Inhibitory …

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New approach to treating dementia using antisense oligonucleotides

In a study of mice and monkeys, NIH funded researchers showed that they could prevent and reverse some of the brain injury caused by the toxic form of a protein called tau. Scientists used a designer compound to prevent and reverse brain damage caused by tau in mice.Credit: Miller lab, Washington University, St. Louis, MO The results, …

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Protein Wnt5a is important in sustaining adult neuron structure in mice hippocampus

Humans and other vertebrates depend on a portion of the brain called the hippocampus for learning, memory and their sense of location. Nerve cell structures in the adult hippocampus are sustained by factors whose identities have remained largely mysterious so far. Now, research led by a Johns Hopkins University biologist Dr. Kuruvilla sheds light on …

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Concussion and Alzheimer’s disease link

New research has found concussions accelerate Alzheimer’s disease-related brain atrophy and cognitive decline in people who are at genetic risk for the condition. The findings, which appear in the journal Brain, show promise for detecting the influence of concussion on neurodegeneration. Brain. Ashton University Moderate-to-severe traumatic brain injury is one of the strongest environmental risk …

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Early detection of Alzheimer’s disease using tau protein biomarker in platelets

Researchers have pioneered the technology that detects pathological oligomeric forms of brain tau protein levels in platelets to diagnose Alzheimer’s disease (AD) and other neurodegenerative disorders.  More importantly, the ratio between this anomalous tau and the normal tau protein can discriminate Alzheimer’s disease patients from normal controls, and are associated with decreased cognitive impairment. This …

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