Animal-study

Muscular dystrophy treatment with Tamoxifen and Raloxifene

Researchers study the use of selective estrogen receptor modulators tamoxifen and raloxifene in patients with muscular dystrophies (MD). Results in an animal study showed significant improvement muscular function. The study findings are published in journal American Journal of Pathology. Animal study results showing improvement in grip strength, running and changes in muscle histology following use …

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Researchers find possible link between autism and nuclear receptor protein LXRβ

Research by University of Houston scientists discovered a possible link between nuclear receptor protein LXRβ (Liver X receptor Beta) and autism spectrum disorder. They found that nuclear receptor LXRβ deletion causes poor development of dentate gyrus, a part of brain’s hippocampus. The dentate gyrus, or DG, is responsible for emotion and memory and is known …

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Understanding molecular mechanisms behind germinal matrix hemorrhage

Researchers have utilized a mouse model to determine the molecular mechanisms underlying germinal matrix hemorrhage. Nearly 12,000 premature infants born annually in the US are affected by neonatal brain hemorrhage which results in mortality and long-term morbidity. Unfortunately, no treatment exists for this condition, and the only preventive measure is steroids before birth, which has …

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New target receptor for treating depression GPR158

Researchers from the Scripps Research Institute find a new target receptor called GPR158 for treating depression. Their research shows that individuals with high levels of above receptor may be more susceptible to depression following chronic stress. “The next step in this process is to come up with a drug that can target this receptor,” says Kirill …

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Effects of flu on brain

Group of researchers from Germany and USA studied effects of influenza virus on brain cells. The study published in the Journal of Neuroscience finds that female mice infected with two different strains of the flu shows changes in structure and function of the hippocampus. These changes persist for one month after infection. The long-term effect …

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Stem cell treatment shows promise for stroke recovery in animal study

A team of researchers  have developed a new treatment for stroke that reduces brain damage and accelerates the brain’s natural healing tendencies in animal models. The findings are published in the journal Translational Stroke Research. Exosomes, shown as small red punctate clusters, are taken up by neurons, shown as green cell extensions surrounding a blue nucleus. …

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Research shows key role of FoxO proteins in osteoarthritis development

Research from scientists at The Scripps Research Institute explains why the risk of osteoarthritis increases as we age and offers a potential avenue for developing new treatments. The study’s findings suggest that FOXO proteins are responsible for the maintenance of healthy cells in the cartilage of our joints. The results are published in journal Science …

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Animal study finds MeXis gene protective against coronary artery disease

UCLA scientists have identified a gene called MeXis that may play a protective role in preventing heart disease. Their findings suggests that this gene acts within macrophages inside clogged arteries to help remove excess cholesterol from blood vessels by controlling cholesterol pump protein expression. Research is published in the journal Nature Medicine. MeXis is an …

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Animal studies show that naturally occurring peptide catestatin has potential as anti-obesity and type 2 diabetes treatment

Research by team from University of California San Diego School of Medicine shows that treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight. In a study published in journal Diabetes, researchers identified catestatins’s role in the recruitment and function …

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