Anti aging drugs focus – Rapamycin

New opinion article by Dr. Mikhail V. Blagosklonny about anti aging drug published in the journal Aging. Drug in focus is rapamycin, which functions by inhibiting mTOR pathway. Similar drugs include everolimus. Normally when over-activated by nutrients and insulin, mTOR acts via S6K to inhibit insulin signaling, thereby causing insulin resistance. The evidence in preclinical … Continue reading Anti aging drugs focus – Rapamycin

Calorie restricted diet promotes intestinal regeneration after injury

Dramatic calorie restriction have long been known to boost healthy lifespan and reduce the risk of heart attack, diabetes and other age-related conditions. In animal studies it is shown to extend life span in most animal species examined. Further research has shown that animals fed restricted-calorie diets are also better able to regenerate numerous tissues … Continue reading Calorie restricted diet promotes intestinal regeneration after injury

Caloric restriction can be protective to brain

Studies of different animal species suggest a link between eating less and living longer, but the molecular mechanisms by which caloric restriction affords protection against disease and extends longevity are not well understood. New clues to help solve the mystery are presented in an article published in the September issue of Aging Cell by scientists … Continue reading Caloric restriction can be protective to brain