Improvements in optical mammography to advance breast cancer diagnostics

Researchers from Politecnico di Milano, Italy report improvements in the design of optical mammography used in diagnosis and monitoring of breast cancer.  They report increase sensitivity by a thousandfold.This research is presented at Biomedical Optics meeting 2018.Schematic diagram of new and improved optical mammography device.Credit: Edoardo FerocinoOptical mammography uses infrared light and is used in conjunction … Continue reading Improvements in optical mammography to advance breast cancer diagnostics

Using ribosomal protein expression patterns as cancer biomarker

A research team at the University of Basel's Biozentrum has investigated the expression of ribosomal proteins in a wide range of human tissues including tumors and discovered a cancer type specific signature. The study is reported in journal Genome Biology. Researchers think that these signature could be used for predicting progression and survival.Gene expression level of individual ribosomal … Continue reading Using ribosomal protein expression patterns as cancer biomarker

Piperlongumine, chemical from Indian pepper plant inhibits enzyme in cancer cells

UT Southwestern Medical Center scientists have uncovered the chemical process behind anti-cancer properties of a spicy Indian pepper plant called the long pepper, whose suspected medicinal properties date back thousands of years. The study is published in the Journal of Biological Chemistry.Dr. Westover's lab used X-ray crystallography to create this molecular model of piperlongumine.Credit: UT … Continue reading Piperlongumine, chemical from Indian pepper plant inhibits enzyme in cancer cells

Calcium channel blockers used for hypertension has potential to block cancer invasion

By screening already approved drugs, the team led by Postdoctoral Researcher Guillaume Jacquemet and Academy Professor Johanna Ivaska has discovered that calcium channel blockers can efficiently stop cancer cell invasion in vitro. Calcium channel blockers are currently used to treat hypertension, also known as high blood pressure, but their potential use in blocking cancer cell … Continue reading Calcium channel blockers used for hypertension has potential to block cancer invasion

Trastuzumab biosimilar (MYL-14010) shown effective in breast cancer clinical trial

Among women with metastatic breast cancer, treatment with a drug that is biosimilar to the breast cancer drug trastuzumab resulted in an equivalent overall response rate at 24 weeks compared with trastuzumab, according to a study published online by JAMA.Trstuzumab BiosimilarsBiological agents, including monoclonal antibodies, have increased the treatment options and greatly improved outcomes for … Continue reading Trastuzumab biosimilar (MYL-14010) shown effective in breast cancer clinical trial

Over expression of protein BRD4 associated with breast cancer metastasis

Researchers have identified a new pathway and with it a protein, BRD4, necessary for breast cancer cells to spread. The findings, which appear in the journal Cancer Research, may provide a new target to suppress breast cancer metastasis.Triple-negative breast cancer is considered the worst subgroup of breast cancer. It is highly aggressive and responds poorly … Continue reading Over expression of protein BRD4 associated with breast cancer metastasis

Synthetic binding protein called "NS1 Monobody" found to inhibit common cancer causing (RAS) mutation

Monobody NS1 binds to H-RAS or K-RAS protein and blocksRAS function by disrupting the protein's ability to form active molecular pairs. Credit: John P. O'Bryan, et al. Researchers at the University of Illinois at Chicago have identified a new way to block the action of genetic mutations found in nearly 30 percent of all cancers. Mutations in genes … Continue reading Synthetic binding protein called "NS1 Monobody" found to inhibit common cancer causing (RAS) mutation

Role of Prolactin Inducible Protein in Breast Cancer

Researchers describe the first evidence linking prolactin inducible protein (PIP) to the immune system's ability to recognize and destroy foreign cells, such as tumor cells. New research in prolactin inducible protein deficient mice that demonstrates the role of prolactin inducible protein  in cell-mediated immunity and suggests that this immune regulatory function may be protective against breast cancer … Continue reading Role of Prolactin Inducible Protein in Breast Cancer

Understanding pathology behind triple negative breast cancer

A study conducted at the Research Institute of the McGill University Health Centre (RI-MUHC) suggests screening breast cancer patients for the prolactin receptor could improve the prognosis for patient and may help them avoid unnecessary and invasive treatments. Using a database of 580 women with triple negative breast cancer (TNBC), the researchers found that survival … Continue reading Understanding pathology behind triple negative breast cancer