Using ribosomal protein expression patterns as cancer biomarker

A research team at the University of Basel's Biozentrum has investigated the expression of ribosomal proteins in a wide range of human tissues including tumors and discovered a cancer type specific signature. The study is reported in journal Genome Biology. Researchers think that these signature could be used for predicting progression and survival.Gene expression level of individual ribosomal … Continue reading Using ribosomal protein expression patterns as cancer biomarker

Piperlongumine, chemical from Indian pepper plant inhibits enzyme in cancer cells

UT Southwestern Medical Center scientists have uncovered the chemical process behind anti-cancer properties of a spicy Indian pepper plant called the long pepper, whose suspected medicinal properties date back thousands of years. The study is published in the Journal of Biological Chemistry.Dr. Westover's lab used X-ray crystallography to create this molecular model of piperlongumine.Credit: UT … Continue reading Piperlongumine, chemical from Indian pepper plant inhibits enzyme in cancer cells

Capsaicin, an active ingredient of chili peppers found to inhibit breast cancer cells in vitro

Capsaicin, an active ingredient of pungent substances such as chili or pepper, inhibits the growth of breast cancer cells. This was reported by a team headed by the Bochum-based scent researcher  Prof. Dr. Dr. Dr. med. habil. Hanns Hatt and Dr. Lea Weber, following experiments in cultivated tumor cells. The study was published in the … Continue reading Capsaicin, an active ingredient of chili peppers found to inhibit breast cancer cells in vitro

New approach to targeted cancer treatment and imaging by utilizing glycosidase activation of glyconaphthalimides.

Scientists from Trinity College Dublin have uncovered a new class of compounds glyconaphthalimides that can be used to target cancer cells with greater specificity than current options allow. The study was published in the journal Chemical Communications.Cervical cancer cells show green fluorescence from enzyme-activated compound.Credit: Eoin Scanlan, Trinity College Dublin.Cancer is difficult to treat, and many current … Continue reading New approach to targeted cancer treatment and imaging by utilizing glycosidase activation of glyconaphthalimides.

New lung cancer biomarker Protein PD-1 for predicting survival

The biomarker PD-1, a protein, could potentially be used to predict survival or disease-free survival of lung cancer patients who have had the tumor surgically removed. This is substantiated by the results of a study conducted under the direction of the Comprehensive Cancer Center (CCC) of MedUni Vienna and Vienna General Hospital, together with MedUni … Continue reading New lung cancer biomarker Protein PD-1 for predicting survival

Research shows possible link between "body clock" and cancer pathogenesis

A new study led by scientists at The Scripps Research Institute (TSRI) describes an unexpected role for proteins involved with our daily “circadian” clocks in influencing cancer growth. The research, published in the journal Molecular Cell, suggests that disruptions in circadian rhythms might leave levels of an important cancer-linked protein, called cMYC, unchecked.“This appears to … Continue reading Research shows possible link between "body clock" and cancer pathogenesis

Lab study shows how metformin can protect against cancer

Researchers at University of California San Diego School of Medicine have identified a previously unknown mechanism that helps fortify the structure and tight junctions between epithelial cells, a basic cell type that lines various body cavities and organs throughout the body, forming a protective barrier against toxins, pathogens, and inflammatory triggers. Breaches of this barrier … Continue reading Lab study shows how metformin can protect against cancer

Protein CPEB4 plays crucial role in melanoma

Spanish National Cancer Research Centre (CNIO) Melanoma Group researchers work tirelessly to identify biomarkers of tumor progression and to validate novel therapeutic targets in melanoma. In particular, their research focuses on discovering features that define the "fingerprint" of this tumor, features that distinguish it from other cancer types. The latest study in this area, published … Continue reading Protein CPEB4 plays crucial role in melanoma

Over expression of protein BRD4 associated with breast cancer metastasis

Researchers have identified a new pathway and with it a protein, BRD4, necessary for breast cancer cells to spread. The findings, which appear in the journal Cancer Research, may provide a new target to suppress breast cancer metastasis.Triple-negative breast cancer is considered the worst subgroup of breast cancer. It is highly aggressive and responds poorly … Continue reading Over expression of protein BRD4 associated with breast cancer metastasis

Role of protein TRAP1 in Prostate cancer

Scientists at The Wistar Institute have demonstrated how a protein called TRAP1 - an important regulator of energy production in healthy and cancerous cells - is an important driver of prostate cancer and appears to be a valuable therapeutic target for the disease. The findings were published in the Journal of Biological Chemistry.TRAP1 is a … Continue reading Role of protein TRAP1 in Prostate cancer