Piperlongumine, chemical from Indian pepper plant inhibits enzyme in cancer cells

UT Southwestern Medical Center scientists have uncovered the chemical process behind anti-cancer properties of a spicy Indian pepper plant called the long pepper, whose suspected medicinal properties date back thousands of years. The study is published in the Journal of Biological Chemistry.Dr. Westover's lab used X-ray crystallography to create this molecular model of piperlongumine.Credit: UT … Continue reading Piperlongumine, chemical from Indian pepper plant inhibits enzyme in cancer cells

Calcium channel blockers used for hypertension has potential to block cancer invasion

By screening already approved drugs, the team led by Postdoctoral Researcher Guillaume Jacquemet and Academy Professor Johanna Ivaska has discovered that calcium channel blockers can efficiently stop cancer cell invasion in vitro. Calcium channel blockers are currently used to treat hypertension, also known as high blood pressure, but their potential use in blocking cancer cell … Continue reading Calcium channel blockers used for hypertension has potential to block cancer invasion

New approach to targeted cancer treatment and imaging by utilizing glycosidase activation of glyconaphthalimides.

Scientists from Trinity College Dublin have uncovered a new class of compounds glyconaphthalimides that can be used to target cancer cells with greater specificity than current options allow. The study was published in the journal Chemical Communications.Cervical cancer cells show green fluorescence from enzyme-activated compound.Credit: Eoin Scanlan, Trinity College Dublin.Cancer is difficult to treat, and many current … Continue reading New approach to targeted cancer treatment and imaging by utilizing glycosidase activation of glyconaphthalimides.

Research shows possible link between "body clock" and cancer pathogenesis

A new study led by scientists at The Scripps Research Institute (TSRI) describes an unexpected role for proteins involved with our daily “circadian” clocks in influencing cancer growth. The research, published in the journal Molecular Cell, suggests that disruptions in circadian rhythms might leave levels of an important cancer-linked protein, called cMYC, unchecked.“This appears to … Continue reading Research shows possible link between "body clock" and cancer pathogenesis

Liquid biopsies for lung cancer could predict best treatment

A blood test could predict how well small-cell lung cancer (SCLC) patients will respond to treatment, according to new research published in Nature Medicine today. Scientists, based at the Cancer Research UK Manchester Institute at The University of Manchester, isolated tumor cells that had broken away from main cancer known as circulating tumor cells (CTCs) … Continue reading Liquid biopsies for lung cancer could predict best treatment

Obese patients with monoclonal gammopathy of undetermined significance (MGUS) are at higher risk of progression to multiple myeloma

New research shows that excess weight increases the risk that a benign blood disorder will progress into multiple myeloma, a cancer of the blood. The study, by a team at Washington University School of Medicine in St. Louis, is published Nov. 18 in the Journal of the National Cancer Institute.Being overweight or obese has been … Continue reading Obese patients with monoclonal gammopathy of undetermined significance (MGUS) are at higher risk of progression to multiple myeloma

Protein CPEB4 plays crucial role in melanoma

Spanish National Cancer Research Centre (CNIO) Melanoma Group researchers work tirelessly to identify biomarkers of tumor progression and to validate novel therapeutic targets in melanoma. In particular, their research focuses on discovering features that define the "fingerprint" of this tumor, features that distinguish it from other cancer types. The latest study in this area, published … Continue reading Protein CPEB4 plays crucial role in melanoma

Arecoline, stimulant from areca nut found to have anticancer properties

Researchers at Winship Cancer Institute of Emory University have discovered  that Arecoline, the stimulant component of areca nuts has anticancer properties. The findings are scheduled for publication in Molecular Cell.This is a ripe areca nut and the the chemical structure of arecolineAreca nuts are chewed for their stimulant effects in many Asian countries, and evidence links the … Continue reading Arecoline, stimulant from areca nut found to have anticancer properties

Over expression of protein BRD4 associated with breast cancer metastasis

Researchers have identified a new pathway and with it a protein, BRD4, necessary for breast cancer cells to spread. The findings, which appear in the journal Cancer Research, may provide a new target to suppress breast cancer metastasis.Triple-negative breast cancer is considered the worst subgroup of breast cancer. It is highly aggressive and responds poorly … Continue reading Over expression of protein BRD4 associated with breast cancer metastasis

Role of protein TRAP1 in Prostate cancer

Scientists at The Wistar Institute have demonstrated how a protein called TRAP1 - an important regulator of energy production in healthy and cancerous cells - is an important driver of prostate cancer and appears to be a valuable therapeutic target for the disease. The findings were published in the Journal of Biological Chemistry.TRAP1 is a … Continue reading Role of protein TRAP1 in Prostate cancer