Novel and unique DNA vaccine to fight effectively against cancer antigen

Scientists at The Wistar Institute and Inovio pharmaceuticals, Inc. have devised a unique deoxyribonucleic acid (DNA) vaccine approach through molecular design to boost the immune responses induced against one of the most important cancer antigen targets. Research results were published in the journal Molecular Therapy.Cancer immunotherapy approaches, designed to harness the body's natural immune defenses … Continue reading Novel and unique DNA vaccine to fight effectively against cancer antigen

Piperlongumine, chemical from Indian pepper plant inhibits enzyme in cancer cells

UT Southwestern Medical Center scientists have uncovered the chemical process behind anti-cancer properties of a spicy Indian pepper plant called the long pepper, whose suspected medicinal properties date back thousands of years. The study is published in the Journal of Biological Chemistry.Dr. Westover's lab used X-ray crystallography to create this molecular model of piperlongumine.Credit: UT … Continue reading Piperlongumine, chemical from Indian pepper plant inhibits enzyme in cancer cells

Capsaicin, an active ingredient of chili peppers found to inhibit breast cancer cells in vitro

Capsaicin, an active ingredient of pungent substances such as chili or pepper, inhibits the growth of breast cancer cells. This was reported by a team headed by the Bochum-based scent researcher  Prof. Dr. Dr. Dr. med. habil. Hanns Hatt and Dr. Lea Weber, following experiments in cultivated tumor cells. The study was published in the … Continue reading Capsaicin, an active ingredient of chili peppers found to inhibit breast cancer cells in vitro

Calcium channel blockers used for hypertension has potential to block cancer invasion

By screening already approved drugs, the team led by Postdoctoral Researcher Guillaume Jacquemet and Academy Professor Johanna Ivaska has discovered that calcium channel blockers can efficiently stop cancer cell invasion in vitro. Calcium channel blockers are currently used to treat hypertension, also known as high blood pressure, but their potential use in blocking cancer cell … Continue reading Calcium channel blockers used for hypertension has potential to block cancer invasion

New approach to targeted cancer treatment and imaging by utilizing glycosidase activation of glyconaphthalimides.

Scientists from Trinity College Dublin have uncovered a new class of compounds glyconaphthalimides that can be used to target cancer cells with greater specificity than current options allow. The study was published in the journal Chemical Communications.Cervical cancer cells show green fluorescence from enzyme-activated compound.Credit: Eoin Scanlan, Trinity College Dublin.Cancer is difficult to treat, and many current … Continue reading New approach to targeted cancer treatment and imaging by utilizing glycosidase activation of glyconaphthalimides.

Trastuzumab biosimilar (MYL-14010) shown effective in breast cancer clinical trial

Among women with metastatic breast cancer, treatment with a drug that is biosimilar to the breast cancer drug trastuzumab resulted in an equivalent overall response rate at 24 weeks compared with trastuzumab, according to a study published online by JAMA.Trstuzumab BiosimilarsBiological agents, including monoclonal antibodies, have increased the treatment options and greatly improved outcomes for … Continue reading Trastuzumab biosimilar (MYL-14010) shown effective in breast cancer clinical trial

Liquid biopsies for lung cancer could predict best treatment

A blood test could predict how well small-cell lung cancer (SCLC) patients will respond to treatment, according to new research published in Nature Medicine today. Scientists, based at the Cancer Research UK Manchester Institute at The University of Manchester, isolated tumor cells that had broken away from main cancer known as circulating tumor cells (CTCs) … Continue reading Liquid biopsies for lung cancer could predict best treatment

Arecoline, stimulant from areca nut found to have anticancer properties

Researchers at Winship Cancer Institute of Emory University have discovered  that Arecoline, the stimulant component of areca nuts has anticancer properties. The findings are scheduled for publication in Molecular Cell.This is a ripe areca nut and the the chemical structure of arecolineAreca nuts are chewed for their stimulant effects in many Asian countries, and evidence links the … Continue reading Arecoline, stimulant from areca nut found to have anticancer properties

Therapeutic Antibody conjugates proven clinically effective with acceptable toxicity

Antibody Drug Conjugates (ADCs) have shown a clearly documented efficacy and acceptable toxicity and can be easily implemented in oncology departments where chemotherapy administration is a routine practice. A similar efficacy with acceptable toxicity has been documented with Antibody Radionuclide Conjugates (ARCs) which need to be injected with the help of a nuclear medicine department … Continue reading Therapeutic Antibody conjugates proven clinically effective with acceptable toxicity