Quantum dot technology to advance molecular cell imaging

Researchers from the University of Illinois at Urbana-Champaign bioengineering team and Mayo Clinic have engineered a new type of molecular probe that can measure and count RNA in cells and tissue without organic dyes. The probe is based on the conventional fluorescence in situ hybridization (FISH) technique, but it relies on compact quantum dots to … Continue reading Quantum dot technology to advance molecular cell imaging

Improvements in optical mammography to advance breast cancer diagnostics

Researchers from Politecnico di Milano, Italy report improvements in the design of optical mammography used in diagnosis and monitoring of breast cancer.  They report increase sensitivity by a thousandfold.This research is presented at Biomedical Optics meeting 2018.Schematic diagram of new and improved optical mammography device.Credit: Edoardo FerocinoOptical mammography uses infrared light and is used in conjunction … Continue reading Improvements in optical mammography to advance breast cancer diagnostics

A new approach to create targeted nanovesicles for cancer treatment

Researchers have used autologous immune cells from the mouse to create nanovesicles to be used in the delivery of drugs to tumors. This technique helped them to create a sufficient number of nanovesicles inexpensively to be used as drug delivery system. This image shows ligands-grafted extracellular vesicles as drug delivery vehicles.Credit: Xin Zou  Cells naturally … Continue reading A new approach to create targeted nanovesicles for cancer treatment

New targeted epigenetic therapy for lymphoma shows promise

New compounds targeting epigenetics have shown promise in treating patients with lymphoma, according to data presented at the Targeted Anticancer Therapies International Congress 2018 in Paris, France. ESMO's phase-I oncology meeting featured early clinical studies with BET inhibitors and EZH2 inhibitors.Dr. Anastasios Stathis, head of the New Drugs Development Unit of the Oncology Institute of … Continue reading New targeted epigenetic therapy for lymphoma shows promise

Hemanthamine found in Daffodils has anti-cancer properties

Researchers from Université Libre de Bruxelles discover that alkaloid found in Daffodils has anti-cancer properties. This alkaloid called haemanthamine works by triggering activation of anti-tumor surveillance pathway. This study was led by Dennis Lafontaine and is published in journal Structure.Structure of Ribosome. Credit ULBResearchers found that this compound binds to the ribosome and blocks the … Continue reading Hemanthamine found in Daffodils has anti-cancer properties

Metabolomics is an useful tool for personalized cancer management

Metabolomics, the analysis of the complete set of metabolites in a defined biological compartment, is a relatively novel approach. Metabolomics studies have been successfully applied to get a better understanding of many diseases, including a number of neoplastic processes. In this context, it is important to underline that cancer patients exhibit metabolic profiles that are … Continue reading Metabolomics is an useful tool for personalized cancer management

Finding new uses for old medication using computer program DrugPredict

Researchers at Case Western Reserve University School of Medicine have developed a computer program called DrugPredict to discover new indications for old drugs. This program matches existing data about FDA-approved drugs to diseases, and predicts potential drug efficacy.In a recent study published in Oncogene, the researchers successfully translated DrugPredict results into the laboratory, and showed … Continue reading Finding new uses for old medication using computer program DrugPredict

Novel and unique DNA vaccine to fight effectively against cancer antigen

Scientists at The Wistar Institute and Inovio pharmaceuticals, Inc. have devised a unique deoxyribonucleic acid (DNA) vaccine approach through molecular design to boost the immune responses induced against one of the most important cancer antigen targets. Research results were published in the journal Molecular Therapy.Cancer immunotherapy approaches, designed to harness the body's natural immune defenses … Continue reading Novel and unique DNA vaccine to fight effectively against cancer antigen

Gene therapy using lipid based nanoparticles

Lipid nanoparticles (SLNs and NLCs) are regarded as highly promising systems for delivering nucleic acids in gene therapy. Literature review by researchers at PharmaNanoGene describes these systems and their main advantages in gene therapy, such as their capacity to protect the gene material against degradation, to facilitate cell and nucleus internalization and to boost the transfection process.View of … Continue reading Gene therapy using lipid based nanoparticles

Research in mice show antioxidants in blue maize have protective effect against metabolic syndrome

A new study shows that a rat model of metabolic syndrome fed a high-sugar and high-cholesterol diet and given blue maize extract showed significant improvement in systolic blood pressure, high density lipoprotein (HDL) cholesterol, and triglyceride levels compared to those not given the extract. The natural antioxidants present in blue maize may help protect against … Continue reading Research in mice show antioxidants in blue maize have protective effect against metabolic syndrome