Local chemotherapy delivered directly to the brain preserves immune system for further immunotherapy in mouse models of glioblastoma multiforme

In experiments on mice with a form of aggressive brain cancer, Johns Hopkins researchers have shown that localized chemotherapy delivered directly to the brain rather than given systemically may be the best way to keep the immune system intact and strong when immunotherapy is also part of the treatment. The researchers say their study results, reported … Continue reading Local chemotherapy delivered directly to the brain preserves immune system for further immunotherapy in mouse models of glioblastoma multiforme

Glioblastoma’s dependence of cholesterol from astrocytes, a possible new therapeutic target

Researchers at University of California San Diego School of Medicine, Ludwig Institute for Cancer Research and The Scripps Research Institute, with colleagues in Los Angeles and Japan, report that depriving deadly brain cancer cells of cholesterol, which they import from neighboring healthy cells, specifically kills tumor cells and caused tumor regression and prolonged survival in … Continue reading Glioblastoma’s dependence of cholesterol from astrocytes, a possible new therapeutic target