HIV

Computational model uncovers progression of HIV infection in brain

University of Alberta research team successfully uncovered the progression of HIV infection in the brain using a new mathematical model. The team is utilizing this model to develop a nasal spray to administer  antiretroviral medication effectively. Their research is published in Journal of Neurovirology. Research was done by PhD student Weston Roda and Prof. Michael …

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New technique of cellular vaccination against HIV

Scientists at The Scripps Research Institute have found a way to tether HIV-fighting antibodies to immune cells, creating a cell population resistant to the virus. Researchers have used membrane-tethered, receptor blocking antibodies to achieve this outcome. Here, cells protected from rhinovirus by membrane-tethered, receptor-blocking antibodies survive well and form colonies. Credit: Jia Xie, Lerner lab, …

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Animal study shows combination of antibodies are effective in HIV

Without antiretroviral drug treatment, the majority of people infected with HIV ultimately develop AIDS, as the virus changes and evolves beyond the body’s ability to control it. But a small group of infected individuals called elite controllers possess immune systems capable of defeating the virus. They accomplish this by manufacturing broadly neutralizing antibodies, which can …

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HIV treatment with immunotherapy using VRC01 shows promise and limitations

Immunotherapy has revolutionized treatment options in oncology, neurology, and many infectious diseases and now there is fresh hope that the same method could be used to treat or functionally cure HIV, according to two related studies from Perelman School of Medicine at the University of Pennsylvania, the University of Alabama at Birmingham (UAB), and the …

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Ibalizumab, a monoclonal antibody for treating Multidrug resistant HIV infection

A new biologic medication – the first for HIV – is showing promise in treating patients with multidrug resistance, according to phase 3 research being presented at IDWeek 2016. Administered intravenously once every two weeks, ibalizumab is a biologic medication called a monoclonal antibody, a genetically engineered molecule that coats immune system cells to protect …

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Researchers focus on using Nanoparticles to improve drug delivery in HIV patients

New research led by the University of Liverpool aims to improve the administration and availability of drug therapies to HIV patients through the use of nanotechnology.  The research, conducted by the collaborative nanomedicine research programme led by Pharmacologist Professor Andrew Owen and Materials Chemist Professor Steve Rannard, examined the use of nanotechnology to improve the …

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