Oncogene

New biomarker based on expression of SHOX2 gene for predicting survival in Gliomas

Researchers at UT Southwestern Medical Center have found a new biomarker for glioma, a common type of brain cancer, that can help doctors determine how aggressive a cancer is and that could eventually help determine the best course of treatment. The findings are published in EBiomedicine. Researchers from the Harold C. Simmons Comprehensive Cancer Center found …

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New method to study RNA G-quadruplexes to understand their role in cancer

An international research team led by the University of Leicester has made a breakthrough advance in understanding about RNA that could pave a new route for the development of anti-cancer drugs. This research is published in Nature Chemical Biology. Professor Ian Eperon and Dr Cyril Dominguez from the University of Leicester’s Institute of Structural and …

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Synthetic binding protein called "NS1 Monobody" found to inhibit common cancer causing (RAS) mutation

Monobody NS1 binds to H-RAS or K-RAS protein and blocksRAS function by disrupting the protein’s ability to form active molecular pairs. Credit: John P. O’Bryan, et al.  Researchers at the University of Illinois at Chicago have identified a new way to block the action of genetic mutations found in nearly 30 percent of all cancers. Mutations in …

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Research identifies role of Oncogenes MDM2, MYCN in Retinoblastoma patients

Researchers at The Saban Research Institute of Children’s Hospital Los Angeles have identified an unsuspected and critical role of the MDM2 oncogene in promoting expression of the MYCN oncogene that is required for growth and survival of retinoblastoma cells. Their results are published in the October 17 online edition of the Nature journal Oncogene. Retinoblastoma …

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Researchers identify molecular mechanism behind cancer-promoting gene H-RasV12 in aggressive cancer cells

Scientists at the University of Birmingham have described a previously-unknown molecular mechanism that could lead to the genetic mutations seen in certain types of aggressive cancer cells, involving a cell’s own transcription machinery. Genetic mutations are fundamental to the spread of cancer cells that form malignant tumours in the body. They are often caused by …

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