Calcium channel blockers used for hypertension has potential to block cancer invasion

By screening already approved drugs, the team led by Postdoctoral Researcher Guillaume Jacquemet and Academy Professor Johanna Ivaska has discovered that calcium channel blockers can efficiently stop cancer cell invasion in vitro. Calcium channel blockers are currently used to treat hypertension, also known as high blood pressure, but their potential use in blocking cancer cell … Continue reading Calcium channel blockers used for hypertension has potential to block cancer invasion

Synthetic binding protein called "NS1 Monobody" found to inhibit common cancer causing (RAS) mutation

Monobody NS1 binds to H-RAS or K-RAS protein and blocksRAS function by disrupting the protein's ability to form active molecular pairs. Credit: John P. O'Bryan, et al. Researchers at the University of Illinois at Chicago have identified a new way to block the action of genetic mutations found in nearly 30 percent of all cancers. Mutations in genes … Continue reading Synthetic binding protein called "NS1 Monobody" found to inhibit common cancer causing (RAS) mutation

Research links collagen structural changes to worse prognosis in pancreatic cancer

(Madison) University of Wisconsin-Madison researchers found first evidence linking a disturbance of the most common protein in the body with a poor outcome in pancreatic cancer. Results of the study are published in the journal Oncotarget. The study reinforces growing evidence that collagen, which forms fibrous networks in skin, tendons and muscles, is intimately involved in … Continue reading Research links collagen structural changes to worse prognosis in pancreatic cancer

Scientists Identify Potential Pancreatic Cancer Target SLC6A14

Researchers have found that a protein called SLC6A14 is overexpressed by several fold in pancreatic tumors taken from patients and in cancerous pancreatic cells lines compared with normal pancreatic tissue or normal pancreatic cells. SLC6A14 transports amino acids into cells to help with cellular metabolism.A blocker of SLC6A14, called α-methyltryptophan, induced amino acid starvation in … Continue reading Scientists Identify Potential Pancreatic Cancer Target SLC6A14

Understaning Pathogenesis of Pancreatic Cancer Metastasis to Liver

Adapted from press release by Technical University of Munich (TUM)Pancreatic cancer is an exceptionally aggressive type of cancer. Frequently, metastases already start to grow in other organs, particularly often in the liver, before the original tumor was even detected. Scientists from the Technical University of Munich (TUM) have now discovered a molecular mechanism, which is … Continue reading Understaning Pathogenesis of Pancreatic Cancer Metastasis to Liver