Stem-Cell

Age-related macular degeneration treated with a stem cell retinal patch

Researchers developed retinal eye patch made from human embryonic stem cells to treat age-related macular degeneration. Researchers grew retinal pigment epithelial cells from stem cells and used synthetic basement membrane to create a retinal patch. Phase 1 clinical trial findings are reported in the journal Nature Biotechnology. Age-related macular degeneration is the most common cause of visual impairment in …

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New body-on-a-chip technology to advance pharmacological research

Researchers from MIT have developed “physiome on chip” technology that could be used to evaluate new drugs and detect side effects before the drugs are tested in human clinical trials. This could be used an alternative to animal testing for pharmacological testing before human clinical trials. Body on a chip. Credit: Felice Frankel They used …

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Mutations play a significant role in skeletal muscle aging

A new study by researchers at Karolinska Institutet in Sweden who investigated mutations in muscle’s stem cells (satellite cells) shows how an unexpectedly high number of mutations which resulted in impaired cell regeneration leading to aging of skeletal muscles. The study is published in Nature Communications. “What is most surprising is the high number of …

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Calorie restricted diet promotes intestinal regeneration after injury

Dramatic calorie restriction have long been known to boost healthy lifespan and reduce the risk of heart attack, diabetes and other age-related conditions. In animal studies it is shown to extend life span in most animal species examined. Further research has shown that animals fed restricted-calorie diets are also better able to regenerate numerous tissues …

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The role of PRC2 in controlling gene activity in human stem cells.

Researchers at the Babraham Institute have revealed a new understanding of the molecular switches that control gene activity in human embryonic stem cells. In the developing embryo and during the specialisation of stem cells, the activity of genes must be tightly controlled so that the correct genes are switched on and off at the right …

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New bright-red fluorescent protein mScarlet to help with cellular staining

After years of trying, biologists have succeeded in creating an extremely bright red fluorescent protein in the lab. This is good news for researchers, including cancer and stem cell researchers, who use fluorescent proteins to track essential cellular processes. The researchers at the University of Amsterdam, the Institut de Biologie structurale and the European Synchrotron …

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Parkinson disease treatment break through – using stem cells to develop dopaminergic neurons.

The first transplantation of stem cells in patients with Parkinson’s disease is almost within reach. However, it remains a challenge for researchers to control stem cells accurately in the lab in order to achieve successful and functional stem cell therapies for patients. “In our preclinical assessments of stem cell-derived dopamine neurons we noticed that the …

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Biosafety studies of Hematopoietic Stem Cell Gene Therapy for Mucopolysaccharidosis I shows promise for human trials

Extensive biosafety studies of hematopoietic stem cell (HSC) gene therapy, intended to replace a protein that patients with the inherited disease mucopolysaccaridosis I (MPS I) cannot produce, support clinical testing of the stem cell-based gene addition approach in MPS I patients. Evidence derived from these studies not only indicates that the HSC gene therapy is …

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