Tag: Animal-study
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Animal studies show that naturally occurring peptide catestatin has potential as anti-obesity and type 2 diabetes treatment
Research by team from University of California San Diego School of Medicine shows that treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight. In a study published in journal Diabetes, researchers identified catestatins’s role in the recruitment and function…
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Research shows efficacy of malarial drug Chloroquine in treating Zika infection
Zika virus remains a major global health risk. In most adults, Zika causes mild flu-like symptoms. But in pregnant women, the virus can cause serious birth defects in babies including microcephaly a neurological condition in which newborns have unusually small heads and fail to develop properly. There is no treatment or way to reverse the…
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Hinokitiol, molecule from Japanese cypress tree shows promise in iron related disorders
Researchers find key molecule that could lead to new therapies for anemia and other iron disorders. New findings reported in journal Science by a multi-institutional team, including researchers from University of Illinois, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Brigham and Women’s Hospital and Northeastern University, could impact whole range of diseases related to iron…
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Novel and unique DNA vaccine to fight effectively against cancer antigen
Scientists at The Wistar Institute and Inovio pharmaceuticals, Inc. have devised a unique deoxyribonucleic acid (DNA) vaccine approach through molecular design to boost the immune responses induced against one of the most important cancer antigen targets. Research results were published in the journal Molecular Therapy. Cancer immunotherapy approaches, designed to harness the body’s natural immune…
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New drug shows promise for COPD and other lung diseases
New research published online in The FASEB Journal reveals a potential drug to combat the life-threatening effects of chronic obstructive pulmonary disease (COPD). Specifically, the study investigated the efficacy of a receptor for advanced glycan end-products (RAGE)-specific antagonist chemical compound, FPS-ZM1, in mice, and found that this compound reverses the inflammatory response and has a…
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New approach to treating dementia using antisense oligonucleotides
In a study of mice and monkeys, NIH funded researchers showed that they could prevent and reverse some of the brain injury caused by the toxic form of a protein called tau. Scientists used a designer compound to prevent and reverse brain damage caused by tau in mice.Credit: Miller lab, Washington University, St. Louis, MO The results,…
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Animal study shows combination of antibodies are effective in HIV
Without antiretroviral drug treatment, the majority of people infected with HIV ultimately develop AIDS, as the virus changes and evolves beyond the body’s ability to control it. But a small group of infected individuals called elite controllers possess immune systems capable of defeating the virus. They accomplish this by manufacturing broadly neutralizing antibodies, which can…
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Protein Wnt5a is important in sustaining adult neuron structure in mice hippocampus
Humans and other vertebrates depend on a portion of the brain called the hippocampus for learning, memory and their sense of location. Nerve cell structures in the adult hippocampus are sustained by factors whose identities have remained largely mysterious so far. Now, research led by a Johns Hopkins University biologist Dr. Kuruvilla sheds light on…
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Research in mice shows molecular mechanism underlying Oxycodone addiction
RGS9-2, a key signaling protein in the brain known to play a critical role in the development of addiction-related behaviors, acts as a positive modulator of oxycodone reward in both pain-free and chronic pain states, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published in the journal Neuropsychopharmacology.…
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