Tag: Breast-cancer
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Improvements in optical mammography to advance breast cancer diagnostics
Researchers from Politecnico di Milano, Italy report improvements in the design of optical mammography used in diagnosis and monitoring of breast cancer. They report increase sensitivity by a thousandfold.This research is presented at Biomedical Optics meeting 2018. Schematic diagram of new and improved optical mammography device.Credit: Edoardo Ferocino Optical mammography uses infrared light and is used…
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Using ribosomal protein expression patterns as cancer biomarker
A research team at the University of Basel’s Biozentrum has investigated the expression of ribosomal proteins in a wide range of human tissues including tumors and discovered a cancer type specific signature. The study is reported in journal Genome Biology. Researchers think that these signature could be used for predicting progression and survival. Gene expression level of individual…
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Piperlongumine, chemical from Indian pepper plant inhibits enzyme in cancer cells
UT Southwestern Medical Center scientists have uncovered the chemical process behind anti-cancer properties of a spicy Indian pepper plant called the long pepper, whose suspected medicinal properties date back thousands of years. The study is published in the Journal of Biological Chemistry. Dr. Westover’s lab used X-ray crystallography to create this molecular model of piperlongumine.Credit:…
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Calcium channel blockers used for hypertension has potential to block cancer invasion
By screening already approved drugs, the team led by Postdoctoral Researcher Guillaume Jacquemet and Academy Professor Johanna Ivaska has discovered that calcium channel blockers can efficiently stop cancer cell invasion in vitro. Calcium channel blockers are currently used to treat hypertension, also known as high blood pressure, but their potential use in blocking cancer cell…
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Trastuzumab biosimilar (MYL-14010) shown effective in breast cancer clinical trial
Among women with metastatic breast cancer, treatment with a drug that is biosimilar to the breast cancer drug trastuzumab resulted in an equivalent overall response rate at 24 weeks compared with trastuzumab, according to a study published online by JAMA. Trstuzumab Biosimilars Biological agents, including monoclonal antibodies, have increased the treatment options and greatly improved…
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Vitamin D and Breast Cancer survival
Women with higher vitamin D levels in their blood following a breast cancer diagnosis had significantly better long-term outcomes, according to new research from Kaiser Permanente and Roswell Park Cancer Institute. The study was published in JAMA Oncology. “We found that women with the highest levels of vitamin D levels had about a 30 percent…
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Synthetic binding protein called “NS1 Monobody” found to inhibit common cancer causing (RAS) mutation
Monobody NS1 binds to H-RAS or K-RAS protein and blocksRAS function by disrupting the protein’s ability to form active molecular pairs. Credit: John P. O’Bryan, et al. Researchers at the University of Illinois at Chicago have identified a new way to block the action of genetic mutations found in nearly 30 percent of all cancers. Mutations in…
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Synthetic binding protein called "NS1 Monobody" found to inhibit common cancer causing (RAS) mutation
Monobody NS1 binds to H-RAS or K-RAS protein and blocksRAS function by disrupting the protein’s ability to form active molecular pairs. Credit: John P. O’Bryan, et al. Researchers at the University of Illinois at Chicago have identified a new way to block the action of genetic mutations found in nearly 30 percent of all cancers. Mutations in…
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Role of Prolactin Inducible Protein in Breast Cancer
Researchers describe the first evidence linking prolactin inducible protein (PIP) to the immune system’s ability to recognize and destroy foreign cells, such as tumor cells. New research in prolactin inducible protein deficient mice that demonstrates the role of prolactin inducible protein in cell-mediated immunity and suggests that this immune regulatory function may be protective against breast cancer…
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