Researchers at Cold Spring Harbor Laboratory (CSHL), led by Professor Adrian Krainer, have developed a method for identifying splicing-based biomarkers for hepatocellular carcinoma (HCC). They have published their findings in journal Genome Research. Different versions, or isoforms, of messenger RNAs generated by the human AFMID gene, are represented, showing their relative prevalence in cancerous (top)… Continue reading Developing new biomarkers for liver cancer with RNA splicing techniques
A chip developed by mechanical engineers at Worcester Polytechnic Institute (WPI) can trap and identify metastatic cancer cells in a small amount of blood drawn from a cancer patient. The breakthrough technology uses a simple mechanical method that has been shown to be more effective in trapping cancer cells than the microfluidic approach employed in… Continue reading Liquid biopsy chip based on carbon nano-tubes to detect circulating cancer cells
Scientists from Trinity College Dublin have uncovered a new class of compounds glyconaphthalimides that can be used to target cancer cells with greater specificity than current options allow. The study was published in the journal Chemical Communications. Cervical cancer cells show green fluorescence from enzyme-activated compound. Credit: Eoin Scanlan, Trinity College Dublin. Cancer is difficult to treat,… Continue reading New approach to targeted cancer treatment and imaging by utilizing glycosidase activation of glyconaphthalimides.
Researchers at UT Southwestern Medical Center have found a new biomarker for glioma, a common type of brain cancer, that can help doctors determine how aggressive a cancer is and that could eventually help determine the best course of treatment. The findings are published in EBiomedicine. Researchers from the Harold C. Simmons Comprehensive Cancer Center found… Continue reading New biomarker based on expression of SHOX2 gene for predicting survival in Gliomas
A blood test could predict how well small-cell lung cancer (SCLC) patients will respond to treatment, according to new research published in Nature Medicine today. Scientists, based at the Cancer Research UK Manchester Institute at The University of Manchester, isolated tumor cells that had broken away from main cancer known as circulating tumor cells (CTCs)… Continue reading Liquid biopsies for lung cancer could predict best treatment
Meningiomas are the most common primary brain tumors, but the term encompasses over a dozen subtypes that range from benign to highly aggressive. Rhabdoid meningiomas are classified as highly aggressive due to their high rates of recurrence and mortality, but the experience and outcomes for patients with this rare form of brain tumor vary widely.… Continue reading Genetic signature for Rhabdoid meningioma discovered
Tumor detection using targeted fluorescent imaging probes is a promising technology that takes advantage of specific molecular events occurring in cancer tissues. However, currently available probes that use this technology fail to maximize their specificity for tumors because of strong off-target signals, and thus, have limited ability to detect small tumors in a short timespan… Continue reading New approach to targeted fluorescent imaging in cancer diagnosis provides improved results
(Madison) University of Wisconsin-Madison researchers found first evidence linking a disturbance of the most common protein in the body with a poor outcome in pancreatic cancer. Results of the study are published in the journal Oncotarget. The study reinforces growing evidence that collagen, which forms fibrous networks in skin, tendons and muscles, is intimately involved in… Continue reading Research links collagen structural changes to worse prognosis in pancreatic cancer