Tag: Cancer-treatment
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Vitamin D and Breast Cancer survival
Women with higher vitamin D levels in their blood following a breast cancer diagnosis had significantly better long-term outcomes, according to new research from Kaiser Permanente and Roswell Park Cancer Institute. The study was published in JAMA Oncology. “We found that women with the highest levels of vitamin D levels had about a 30 percent…
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Making T-Cell receptor gene therapy safer by domain swapping
The human body produces T cells to recognize and fight disease. Each T cell has a unique T cell receptor (or TCR) on its surface that surveils small fragments of proteins presented by other cells. Upon detecting evidence of cancer or infection, a subset of T cells binds the diseased cells and orchestrates their elimination.…
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Multi drug resistant cancer is associated with loss of TP53TG1 molecule
A new study by researchers at the Bellvitge Biomedical Research Institute (IDIBELL) has found a cause of multiple resistance in cancer chemotherapy. They discovered that 10% of colon and stomach tumors present wit loss of a molecule called TP53TG1. The functionof TP53TG1 is to prevent activation of YBX1 protein. Without surveillance of TP53TG1 in these…
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Synthetic binding protein called "NS1 Monobody" found to inhibit common cancer causing (RAS) mutation
Monobody NS1 binds to H-RAS or K-RAS protein and blocksRAS function by disrupting the protein’s ability to form active molecular pairs. Credit: John P. O’Bryan, et al. Researchers at the University of Illinois at Chicago have identified a new way to block the action of genetic mutations found in nearly 30 percent of all cancers. Mutations in…
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Synthetic binding protein called “NS1 Monobody” found to inhibit common cancer causing (RAS) mutation
Monobody NS1 binds to H-RAS or K-RAS protein and blocksRAS function by disrupting the protein’s ability to form active molecular pairs. Credit: John P. O’Bryan, et al. Researchers at the University of Illinois at Chicago have identified a new way to block the action of genetic mutations found in nearly 30 percent of all cancers. Mutations in…
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New approach to treating cancer with therapeutic short interfering RNA (siRNA) delivered by nanohydrogel nanoparticles
A novel targeted therapy using nanoparticles has enabled researchers at the Georgia Institute of Technology to purge ovarian tumors in limited, in vivo tests in mice. “The dramatic effect we see is the massive reduction or complete eradication of the tumor, when the ‘nanohydrogel’ treatment is given in combination with existing chemotherapy,” said chief researcher…
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