A research team at the University of Basel’s Biozentrum has investigated the expression of ribosomal proteins in a wide range of human tissues including tumors and discovered a cancer type specific signature. The study is reported in journal Genome Biology. Researchers think that these signature could be used for predicting progression and survival. Gene expression level of individual… Continue reading Using ribosomal protein expression patterns as cancer biomarker
UT Southwestern Medical Center scientists have uncovered the chemical process behind anti-cancer properties of a spicy Indian pepper plant called the long pepper, whose suspected medicinal properties date back thousands of years. The study is published in the Journal of Biological Chemistry. Dr. Westover’s lab used X-ray crystallography to create this molecular model of piperlongumine.Credit:… Continue reading Piperlongumine, chemical from Indian pepper plant inhibits enzyme in cancer cells
Monobody NS1 binds to H-RAS or K-RAS protein and blocksRAS function by disrupting the protein’s ability to form active molecular pairs. Credit: John P. O’Bryan, et al. Researchers at the University of Illinois at Chicago have identified a new way to block the action of genetic mutations found in nearly 30 percent of all cancers. Mutations in… Continue reading Synthetic binding protein called “NS1 Monobody” found to inhibit common cancer causing (RAS) mutation
Monobody NS1 binds to H-RAS or K-RAS protein and blocksRAS function by disrupting the protein’s ability to form active molecular pairs. Credit: John P. O’Bryan, et al. Researchers at the University of Illinois at Chicago have identified a new way to block the action of genetic mutations found in nearly 30 percent of all cancers. Mutations in… Continue reading Synthetic binding protein called "NS1 Monobody" found to inhibit common cancer causing (RAS) mutation
Scientists at Washington State University and Johns Hopkins Medical School have discovered a fast, noninvasive method that could lead to the early diagnosis of colorectal cancer. Using ultrasensitive, high-speed technology, the researchers identified a suite of molecules in the feces of mice that signifies the presence of precancerous polyps. This “metabolic fingerprint” matches changes in… Continue reading Noninvasive test to find fat in feces to diagnose Colorectal cancer
Early diagnosis of cancer is linked to better survival rates. Unfortunately, participation rates for cancer screening worldwide are low even when screening programmes are free. The ESMO 2016 Congress is showcasing five studies (1) on this important area of cancer management which look at alternative ways to overcome barriers and improve screening rates Professor J-F… Continue reading Improving participation in cancer screening should be a priority
Researchers from Boston University School of Medicine have discovered a possible strategy to treat colon cancers that are caused by the mutant KRAS gene, which is responsible for approximately half of all colon cancer cases. The findings, which appear online in the journal Molecular Cancer Research, may lead to better therapeutic agents to treat this… Continue reading Genetic targets in Colorectal Cancer: role of KRAS, MEK and TAK1 genes Identified.
The discovery, published online by Oncotarget journal, may lead to new therapies in managing patients with Colorectal Cancer (CRC). CRC is a complex disease caused by several genetic mutations and their consequences. In more than 80-percent of CRC patients, some of these mutations can lead to an increase in ?-catenin, a vital protein, leading to… Continue reading Research indicates role of protein c-Cbl in Colorectal Cancer