Tag: Diabetes

• New approach to treating Obesity with fat burning molecule ABX300

  A small molecule ABX300 could provide valuable help in combating the global epidemic of obesity. When it was fed to obese mice, the animals’ metabolism sped up and their excess weight was shed. It is doing so by recruiting the help of a body’s own genes in countering the effects of a high-fat diet. The…

  Sreeram Penna

  December 7, 2016

• Understanding signaling pathway that creates brown fat to help in fight against obesity and diabetes

  A signaling pathway in fat cells may one day provide the key to better treatments for obesity, according to new research by scientists at the Perelman School of Medicine at the University of Pennsylvania. They reported their findings in Genes & Development. This image shows adipose tissue, with fat droplets in greenand blood vessels in…

  Sreeram Penna

  December 6, 2016

• Research discovers beneficial role of omega-3 fatty acids on brown fat

  Omega-3 fatty acids are able to stimulate the activation of brown and beige adipose tissues, a discovery that would promote the development of new therapies for obesity and other metabolism diseases, according to a research study published in the journal Nature Communications under the supervision of Professor Francesc Villarroya, from the Department of Biochemistry and…

  Sreeram Penna

  November 21, 2016

• Researchers discover role of molecular switch TSC22D4 in glucose metabolism

  A Research team led by the metabolism expert Professor Stephan Herzig, director of the Institute for Diabetes and Cancer at Helmholtz Zentrum München (IDC), has discovered a new mechanism that is responsible for the regulation of the glucose metabolism. The transforming growth factor beta 1-stimulated clone 22 D4, abbreviated TSC22D4, acts as a molecular switch…

  Sreeram Penna

  November 15, 2016

• Role of nerve growth factor in glucose metabolism

  Research led by a Johns Hopkins University biologist demonstrates the workings of a biochemical pathway that helps control glucose in the bloodstream, a development that could potentially lead to treatments for diabetes. In a paper published in the current issue of Developmental Cell, Jessica Houtz, a graduate student working with Rejji Kuruvilla in the Department…

  Sreeram Penna

  November 14, 2016

• Medical device that activates heat shock response found helpful in Diabetic patients

  Although effective for the treatment of diabetes, exercise is sometimes difficult for overweight or elderly people. A new wearable medical device developed by Kumamoto University has been found to effect visceral fat loss and improve blood glucose (sugar). The current study reports clinical trial results for optimal use frequency. Type 2 diabetes is a disease…

  Sreeram Penna

  November 13, 2016

• Protein galectin-3 plays role in insulin resistance and glucose intolerance

  By removing the protein galectin-3 (Gal3), a team of investigators led by University of California School of Medicine researchers were able to reverse diabetic insulin resistance and glucose intolerance in mouse models of obesity and diabetes. By binding to insulin receptors on cells, Gal3 prevents insulin from attaching to the receptors resulting in cellular insulin…

  Sreeram Penna

  November 5, 2016

• Researchers reveal wound healing function of heat shock protien 60 (Hsp60) in mice

  National Institutes of Health researchers have identified a novel role for a gene known as heat shock protein 60 (Hsp60), finding that it is critical in tissue regeneration and wound healing. The study found that topical treatment of an Hsp60-containing gel dramatically accelerates wound closure in a diabetic mouse model. The study also describes the…

  Sreeram Penna

  October 30, 2016

• Sleep loss and change in gut microbiota

  Results from a new clinical study conducted at Uppsala University suggest that curtailing sleep alters the abundance of bacterial gut species that have previously been linked to compromised human metabolic health. The new article is published in the journal Molecular Metabolism. Changes in the composition and diversity of the gut microbiota have been associated with…

  Sreeram Penna

  October 26, 2016

• New molecule Beta-LGND2 may help fight obesity

  New research, published online in The FASEB Journal, suggests that activation of a chemical called Beta-LGND2 by the estrogen receptor Beta (ER-Beta) reduces obesity and metabolic diseases in mice by converting bad fat (white fat) to good fat (brown fat). This is significant as brown fat increases metabolism and may facilitate weight loss. “Although there…

  Sreeram Penna

  October 15, 2016