Digital PCR found effective and reproducible in a research study

21 independent labs quantified a rare single nucleotide variant using digital PCR (dPCR) with high reproducibility between labs, demonstrating the method’s potential for routine clinical testing, according to a study published in Analytical Chemistry. The research study is the first to examine the reproducibility of digital PCR between such a large number of laboratories at… Continue reading Digital PCR found effective and reproducible in a research study

Novel and unique DNA vaccine to fight effectively against cancer antigen

Scientists at The Wistar Institute and Inovio pharmaceuticals, Inc. have devised a unique deoxyribonucleic acid (DNA) vaccine approach through molecular design to boost the immune responses induced against one of the most important cancer antigen targets. Research results were published in the journal Molecular Therapy. Cancer immunotherapy approaches, designed to harness the body’s natural immune… Continue reading Novel and unique DNA vaccine to fight effectively against cancer antigen

Obesity genes: role of foraging gene in fruit fly

A University of Toronto study on fruit flies has uncovered a gene that could play a key role in obesity in humans. The paper published online this month in Genetics examines a “foraging gene” humans share in common with the flies, which plays multiple roles and is found in similar places, such as the nervous… Continue reading Obesity genes: role of foraging gene in fruit fly

New approach to treating dementia using antisense oligonucleotides

In a study of mice and monkeys, NIH¬†funded researchers showed that they could prevent and reverse some of the brain injury caused by the toxic form of a protein called tau. Scientists used a designer compound to prevent and reverse brain damage caused by tau in mice.Credit:¬†Miller lab, Washington University, St. Louis, MO The results,… Continue reading New approach to treating dementia using antisense oligonucleotides

Obesity related Epigenetic changes in DNA

Obesity has been linked to “letter” changes at many different sites in the genome, yet these differences do not fully explain the variation in people’s body mass index (BMI) or why some overweight people develop health complications while others don’t. A large study from Boston Children’s Hospital, the University of Edinburgh, the Harvard School of… Continue reading Obesity related Epigenetic changes in DNA

Role of retroviruses in evolution of human brain

Over millions of years, retroviruses have been incorporated into our human DNA, where they today make up almost 10 percent of the total genome. A research group at Lund University in Sweden has now discovered a mechanism through which these retroviruses may have an impact on gene expression. This means that they may have played… Continue reading Role of retroviruses in evolution of human brain

Effects of telomeres length on stem cells

Ever since researchers connected the shortening of telomeres the protective structures on the ends of chromosomes to aging and disease, the race has been on to understand the factors that govern telomere length. Now, Scientists at the Salk Institute have found that a balance of elongation and trimming in stem cells results in telomeres that… Continue reading Effects of telomeres length on stem cells

New approach to treating Obesity with fat burning molecule ABX300

A small molecule ABX300 could provide valuable help in combating the global epidemic of obesity. When it was fed to obese mice, the animals’ metabolism sped up and their excess weight was shed. It is doing so by recruiting the help of a body’s own genes in countering the effects of a high-fat diet. The… Continue reading New approach to treating Obesity with fat burning molecule ABX300

Dutch universities collaborate on big data in health to understand disease process

Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalized treatment. Six Dutch universities are combining forces to chart the different disease processes for a range of common… Continue reading Dutch universities collaborate on big data in health to understand disease process

Pandemic strain blamed for re-emergence of Syphilis

Syphilis has plagued humankind for over 500 years. After the first reported outbreaks struck Europe in 1495, the disease spread rapidly to other continents and swelled to a global pandemic. When treatment with the antibiotic penicillin became available in the mid-twentieth century, infection rates started to decrease dramatically. Strikingly, however, infection with the bacteria Treponema… Continue reading Pandemic strain blamed for re-emergence of Syphilis