Growth Differentiation Factor 15, or GDF15, is a member of the cytokine superfamily proteins called transforming growth factor-beta (TGF-β).GDF15 is a stress-responsive cytokine produced in response to various cellular stress and tissue injury types. It is found in numerous tissues throughout the body, including the liver, kidney, and heart. GDF15 has gained significant attention for its potential involvement in regulating body weight and appetite, as studies have shown it increases in response to conditions like obesity, heart failure, and cancer. Its exact biological functions are still being investigated, but GDF15 appears to play a role in inflammation and cardiovascular disease and may influence metabolic processes. Ongoing research delves into the therapeutic potential of modulating GDF15 levels, particularly in metabolic and cardiovascular diseases.