The National Institutes of Health plans to expand its Encyclopedia of DNA Elements (ENCODE) Project, a genomics resource used by many scientists to study human health and disease. Funded by the National Human Genome Research Institute (NHGRI), part of NIH, the ENCODE Project is generating a catalog of all the genes and regulatory elements the… Continue reading National Institutes of Health to expand ENCODE project
Scientists at The Wistar Institute have demonstrated how a protein called TRAP1 – an important regulator of energy production in healthy and cancerous cells – is an important driver of prostate cancer and appears to be a valuable therapeutic target for the disease. The findings were published in the Journal of Biological Chemistry. TRAP1 is… Continue reading Role of protein TRAP1 in Prostate cancer
Meningiomas are the most common primary brain tumors, but the term encompasses over a dozen subtypes that range from benign to highly aggressive. Rhabdoid meningiomas are classified as highly aggressive due to their high rates of recurrence and mortality, but the experience and outcomes for patients with this rare form of brain tumor vary widely.… Continue reading Genetic signature for Rhabdoid meningioma discovered
A research team at the Krembil Research Institute has discovered that a signaling pathway which controls blood vessel development in the brain has the ability to stop brain tumor formation in animal models of medulloblastoma, the most common malignant brain tumor diagnosed in children. The findings, published in the journal eLife, are the first to… Continue reading Signaling pathway that controls blood vessel development in brain has ability stop medulloblastoma, a cerebellar tumor.
A research effort at the Centre for Genomic Regulation in Barcelona, Spain, reveals new molecular mechanisms of Huntington’s disease. The results, published in The Journal of Clinical Investigation, question the approaches used up to now for treatment of the disease. They also point to messenger RNA as a key pathogenic component that will make it… Continue reading Research finds role of Messenger RNA in Huntington’s disease patholgy
A novel targeted therapy using nanoparticles has enabled researchers at the Georgia Institute of Technology to purge ovarian tumors in limited, in vivo tests in mice. “The dramatic effect we see is the massive reduction or complete eradication of the tumor, when the ‘nanohydrogel’ treatment is given in combination with existing chemotherapy,” said chief researcher… Continue reading New approach to treating cancer with therapeutic short interfering RNA (siRNA) delivered by nanohydrogel nanoparticles
Researchers at Karolinska Institutet have measured the absolute numbers of short, non-coding, RNA sequences in individual embryonic stem cells. The new method could improve the understanding of how our genes are regulated and different cell types develop. When information in our genes is used, for example to build a protein, it is first translated to… Continue reading Researchers map short RNA molecules in single cell
Scientists at The Australian National University (ANU) and Heidelberg University in Germany have found an essential component in the DNA repair process which could open the door to the development of new cancer drugs. Lead researcher Associate Professor Tamás Fischer from ANU said the research found hybrid structures composed of DNA and RNA play an… Continue reading Study finds that hybrid structures composed of DNA and RNA and enzyme RNase H play important role in DNA repair