Organs-on-chip
Organs-on-chip are innovative devices that mimic the complex biological functions of specific human organs on a microscale. These chips, typically made from a clear, flexible polymer, contain tiny channels lined with living human cells and tissues that replicate the physiological and mechanical environment of whole organs. By simulating the activities, mechanics, and physiological responses of human organs, organs-on-chip provide a more accurate and ethical alternative to traditional animal testing for drug development and disease modeling. This organs-on-chip technology represents a significant advancement in the field of biomedical research, enabling scientists to study diseases and test pharmaceuticals in a human-relevant and organ-specific context. The applications of organs-on-chip range from personalized medicine, where they can predict an individual’s response to a drug, to the study of complex diseases like cancer or Alzheimer’s in a controlled and replicable environment.
Organs-on-chip
Latest Posts
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Cholangiocarcinoma-On-Chip to Revolutionize Research and Precision Medicine
Researchers have developed a groundbreaking “cholangiocarcinoma-on-chip” model, leveraging organ-on-chip technology to mimic the complex tumor microenvironment of this aggressive cancer. This personalized microfluidic device, incorporating various cell types from patient specimens, offers a novel approach to precision…
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New microfluidic system using artificial membrane keep brain tissue viable for a longer duration
Researchers at the RIKEN Center for Biosystems Dynamics Research in Japan have developed a new system for keeping tissue viable for long-term study once transferred from an animal to a culture medium. The new system uses a…
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New body-on-a-chip technology to advance pharmacological research
Researchers from MIT have developed “physiome on chip” technology that could be used to evaluate new drugs and detect side effects before the drugs are tested in human clinical trials. This could be used an alternative to…
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I-Wire, a new Heart-on-a-Chip device to study biomechanical properties of heart
Scientists at Vanderbilt University have created a 3D organ-on-a-chip that can mimic the biomechanical properties of the heart. The device and the results of initial experiments are reported in the journal Acta Biomaterialia (for links see below). View…
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Researchers develop in vitro model of brain for research
Harvard University researchers have developed a multiregional brain-on-a-chip that models the connectivity between three distinct regions of the brain. The in vitro model was used to extensively characterize the differences between neurons from different regions of the…
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NeuroVascular Unit on a chip created to mimic functions of Blood-brain barrier
The blood-brain barrier is a network of specialized cells that surrounds the arteries and veins within the brain. It forms a unique gateway that both provides brain cells with the nutrients they require and protects them from…
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