Tag: Parkinsons-Disease
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NeuralTree: closed-loop neuromodulation system-on-chip
Researchers from École Polytechnique Fédérale de Lausanne have developed NeuralTree, a closed-loop neuromodulation system-on-chip that detects and alleviates disease symptoms. It uses a 256-channel high-resolution sensing array and an energy-efficient machine-learning processor to extract and classify biomarkers for accuracy in symptom prediction. It uses data from real patients’ EEG and iEEG epilepsy datasets, as well…
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Role of calcium in Parkinson’s disease
The international team, led by the University of Cambridge found that excess levels of calcium in brain cells may lead to the formation of toxic clusters that are the hallmark of Parkinson’s disease. Their research found that calcium can mediate the interaction between small membranous structures inside nerve endings, which are important for neuronal signalling…
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Cortisol and Parkinson’s Disease
Research team from Daegu Gyeongbuk Institute Of Science And Technology (DGIST) has performed a high-throughput screening method to identify drug candidates that promote dopaminergic neuronal cell activation by inducing the expression of the parkin protein, the cell protection gene which can inhibit the death of dopaminergic neurons. The results of study are published in Scientific…
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Squalamine shows promise as potential treatment for Parkinson’s disease in lab studies
A naturally-occurring compound has been found to block a molecular process thought to underlie Parkinson’s Disease and to suppress its toxic products, scientists have reported. The findings, although only preliminary, suggest that the compound, called squalamine, could be exploited in various ways as the basis of a potential treatment for Parkinson’s Disease. Credit: Geralt/pixabay The…
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Combating Aging by removing damaged mitochondrial DNA
Researchers from UCLA and Caltech have made discoveries that might help slow and potentially reverse the process of aging in cells. They generated new methods that allow identification of factors that selectively remove damaged mitochondrial DNA, which will affect the process of aging at the cellular level. Aging is, in part, due to changes in…
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Parkinson disease treatment break through – using stem cells to develop dopaminergic neurons.
The first transplantation of stem cells in patients with Parkinson’s disease is almost within reach. However, it remains a challenge for researchers to control stem cells accurately in the lab in order to achieve successful and functional stem cell therapies for patients. “In our preclinical assessments of stem cell-derived dopamine neurons we noticed that the…
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