A Polygenic Risk Score is a quantitative measure that assesses an individual’s genetic susceptibility to a particular disease or trait based on the cumulative effect of multiple genetic variants. Polygenic Risk Score (PRS) is calculated by aggregating the impact of many minor genetic variations, each contributing to a slight increase or decrease in the risk of developing a disease or exhibiting a particular trait. The PRS is derived from genome-wide association studies (GWAS) that identify associations between genetic markers and diseases or traits across the genome. By summing the effects of these markers, weighted by their associated risk, a polygenic Risk Score (PRS) provides an individualized risk estimate. This tool is increasingly used in research and clinical settings to enhance understanding of genetic predispositions, inform personalized medicine, and potentially guide lifestyle and medical interventions to mitigate risk. It promises to improve disease prediction, prevention strategies, and tailoring treatments to individuals’ genetic profiles. However, its implementation and interpretation in clinical practice require careful consideration of its limitations and ethical implications.