Developing new biomarkers for liver cancer with RNA splicing techniques

Researchers at Cold Spring Harbor Laboratory (CSHL), led by Professor Adrian Krainer, have developed a method for identifying splicing-based biomarkers for hepatocellular carcinoma (HCC). They have published their findings in journal Genome Research. Different versions, or isoforms, of messenger RNAs generated by the human AFMID gene, are represented, showing their relative prevalence in cancerous (top)… Continue reading Developing new biomarkers for liver cancer with RNA splicing techniques

Animal study finds MeXis gene protective against coronary artery disease

UCLA scientists have identified a gene called MeXis that may play a protective role in preventing heart disease. Their findings suggests that this gene acts within macrophages inside clogged arteries to help remove excess cholesterol from blood vessels by controlling cholesterol pump protein expression. Research is published in the journal Nature Medicine. MeXis is an… Continue reading Animal study finds MeXis gene protective against coronary artery disease

New approach to treating dementia using antisense oligonucleotides

In a study of mice and monkeys, NIH funded researchers showed that they could prevent and reverse some of the brain injury caused by the toxic form of a protein called tau. Scientists used a designer compound to prevent and reverse brain damage caused by tau in mice.Credit: Miller lab, Washington University, St. Louis, MO The results,… Continue reading New approach to treating dementia using antisense oligonucleotides

New approach to treating Obesity with fat burning molecule ABX300

A small molecule ABX300 could provide valuable help in combating the global epidemic of obesity. When it was fed to obese mice, the animals’ metabolism sped up and their excess weight was shed. It is doing so by recruiting the help of a body’s own genes in countering the effects of a high-fat diet. The… Continue reading New approach to treating Obesity with fat burning molecule ABX300

Research shows meninges contain neural progenitor stem cells

In a cross-domain study directed by professor Peter Carmeliet, researchers discovered unexpected cells in the protective membranes that enclose the brain, the so-called meninges. These ‘neural progenitors’ – or stem cells that differentiate into different kinds of neurons – are produced during embryonic development. These findings show that the neural progenitors found in the meninges… Continue reading Research shows meninges contain neural progenitor stem cells

Research finds role of Messenger RNA in Huntington’s disease patholgy

A research effort at the Centre for Genomic Regulation in Barcelona, Spain, reveals new molecular mechanisms of Huntington’s disease. The results, published in The Journal of Clinical Investigation, question the approaches used up to now for treatment of the disease. They also point to messenger RNA as a key pathogenic component that will make it… Continue reading Research finds role of Messenger RNA in Huntington’s disease patholgy

New method to study RNA G-quadruplexes to understand their role in cancer

An international research team led by the University of Leicester has made a breakthrough advance in understanding about RNA that could pave a new route for the development of anti-cancer drugs. This research is published in Nature Chemical Biology. Professor Ian Eperon and Dr Cyril Dominguez from the University of Leicester’s Institute of Structural and… Continue reading New method to study RNA G-quadruplexes to understand their role in cancer

New approach to treating cancer with therapeutic short interfering RNA (siRNA) delivered by nanohydrogel nanoparticles

A novel targeted therapy using nanoparticles has enabled researchers at the Georgia Institute of Technology to purge ovarian tumors in limited, in vivo tests in mice. “The dramatic effect we see is the massive reduction or complete eradication of the tumor, when the ‘nanohydrogel’ treatment is given in combination with existing chemotherapy,” said chief researcher… Continue reading New approach to treating cancer with therapeutic short interfering RNA (siRNA) delivered by nanohydrogel nanoparticles

Researchers map short RNA molecules in single cell

Researchers at Karolinska Institutet have measured the absolute numbers of short, non-coding, RNA sequences in individual embryonic stem cells. The new method could improve the understanding of how our genes are regulated and different cell types develop. When information in our genes is used, for example to build a protein, it is first translated to… Continue reading Researchers map short RNA molecules in single cell