Amino acids link gut microbiome to obesity

Researchers at Lund University in Sweden have discovered a new link between gut bacteria and obesity. They found that certain amino acids in our blood can be connected to both obesity and the composition of the gut microbiome.

Increasing number of research studies indicate that our gut microbiome does play an important role in our health. It affects our metabolism and can be linked to obesity, cardiovascular disease and type 2 diabetes.

Previous studies have shown that people with these diseases have varying occurrence of different metabolites, i.e. small molecules or metabolic residues, in the bloodstream. The aim of the new study was therefore to identify metabolites in the blood that can be linked to obesity (high body mass index, BMI) and to investigate whether these obesity-related metabolites affect the composition of the bacterial flora in stool samples.

The researchers analysed blood plasma and stool samples from 674 participants in the Malmö Offspring Study. They found 19 different metabolites that could be linked to the person’s BMI; glutamate and so-called BCAA (branched-chain and aromatic amino acids) had the strongest connection to obesity. They also found that the obesity-related metabolites were linked to four different intestinal bacteria (Blautia, Dorea and Ruminococcus in the Lachnospiraceae family, and SHA98).

“The differences in BMI were largely explained by the differences in the levels of glutamate and branched-chain and aromatic amino acids. This indicates that the metabolites and gut bacteria interact, rather than being independent of each other”, says Marju Orho-Melander, professor of genetic epidemiology at Lund University.

By far the strongest risk factor for obesity in the study, glutamate, has been associated with obesity in previous studies, and BCAA has been used to predict the future onset of type 2 diabetes and cardiovascular disease.

“This means that future studies should focus more on how the composition of gut bacteria can be modified to reduce the risk of obesity and associated metabolic diseases and cardiovascular disease”, says Marju Orho-Melander. “To get there, we first need to understand what a healthy normal gut flora looks like, and what factors impact the bacterial composition. This requires large population studies, like the Malmö Offspring Study, as well as intervention studies”, she concludes.

Citation: Ottosson, Filip, Louise Brunkwall, Ulrika Ericson, Peter M. Nilsson, Peter Almgren, Céline Fernandez, Olle Melander, and Marju Orho-Melander. “Connection between BMI related plasma metabolite profile and gut microbiota.” The Journal of Clinical Endocrinology & Metabolism, 2018. doi:10.1210/jc.2017-02114.

Adapted from press release by the Lund University.