Researchers from Michigan State University propose a novel non-invasive magnetic particle imaging (MPI) to monitor chemotherapy release in vivo. This method employs superparamagnetic nanoparticles as the contrast agent to monitor drug release in the body.
In this study researchers designed iron oxide nanocomposite loaded with a chemotherapy drug doxorubicin which serves as a drug delivery system and magnetic particle imaging (MPI) quantification tracer. They showed that nanocomposite-induced MPI signal changes display a linear correlation with the release rate of doxorubicin over time.
Researchers performed this study in both in-vitro cell cultures and murine breast cancer model.
Implications: In vivo drug monitoring technologies are important as they monitor adequate drug release at the site of tumors. Being non-invasive as it is easier to perform and repeat.
This research is published Nano Letters (ACS publications)
Researchers from Environmental Working Group conducted a cumulative assessment of cancer risk due to carcinogenic compounds found in drinking water. They used a novel analytical framework that calculated their combined health impacts. Results of the study showed that these substances would result in more than 100,000 cancer cases nationwide. Findings of the study are published in journal Heliyon.
In this study they utilized comprehensive nationwide dataset for contaminant occurrence in community water systems in the United States. This dataset contains water quality profiles for 48,363 community water systems. The dataset does not include water quality information on private wells .
Most of the increased cancer risk is due to contamination with arsenic, disinfection byproducts and radioactive elements such as uranium and radium. Water systems with the highest risk tend to serve smaller communities and rely on groundwater. These communities often need improved infrastructure and resources to provide safe drinking water to their residents. However, large surface water systems contribute a significant share of the overall risk due to the greater population served and the consistent presence of disinfection byproducts.
This research highlights importance of much needed improvement in infrastructure to provide clean and safe drinking water.