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Study reveals potential new treatment target Nuak1 kinase to prevent accumulation of protein in early Alzheimer’s disease
Taking a pill that prevents the accumulation of toxic molecules in the brain might someday help prevent or delay Alzheimer’s disease, according to scientists at Baylor College of Medicine, Texas Children’s Hospital and Johns Hopkins University School of Medicine. The study, published today in Cell Press journal Neuron, took a three-pronged approach to help subdue…
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Novel cancer therapy developed at University of Oklahoma based on photothermal therapy using carbon nanotubes
University of Oklahoma researchers have collaborated to design a novel, non-invasive cancer therapy that could eliminate tumors without affecting the healthy cells in the body. The cancer therapy targets specific cancer cells using single-walled carbon nanotubes that bind directly to the tumor, then are heated with near-infrared light. The OU photothermal therapy is most effective…
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Researchers focus on using Nanoparticles to improve drug delivery in HIV patients
New research led by the University of Liverpool aims to improve the administration and availability of drug therapies to HIV patients through the use of nanotechnology. The research, conducted by the collaborative nanomedicine research programme led by Pharmacologist Professor Andrew Owen and Materials Chemist Professor Steve Rannard, examined the use of nanotechnology to improve the…
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Understanding Leukemia cell movement gives clues to its resistance to treatment
This is a high-resolution render of unique environments in the bone marrow (blue, purple and green) as they are invaded and populated by leukemia cells (yellow).Credit: Edwin Hawkins and Delfim Duarte/Imperial College London New research is shedding light on how leukaemia cells can survive cancer treatment, suggesting new possibilities for stopping them in their tracks. Leukaemia has…
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Modified bacterial genes used to boost electrical conductivity in human cells
(Durham) Duke University biomedical engineers have harvested genes for ion channels from bacteria that, with a few tweaks, can create and enhance electrical signaling in human cells, making the cells more electrically excitable. The technique could one day be used to treat cardiac arrhythmia or to restore electrical functions to scarred heart or nervous system tissues.…
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Researchers use computer simulation to understand structure of virus
(Pittsburg) Researchers led by Carnegie Mellon University physicist Markus Deserno and University of Konstanz (Germany) chemist Christine Peter have developed a computer simulation that crushes viral capsids. By allowing researchers to see how the tough shells break apart, the simulation provides a computational window for looking at how viruses and proteins assemble. The study is…
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Genome-wide association study identifies risk genes in African Americans with inflammatory bowel disease
In the first genome-wide association study (GWAS) of genetic risk factors for inflammatory bowel disease in African Americans, a research team has identified two regions of the genome (loci) associated with ulcerative colitis only in people of African descent. The study was led by Emory University, the Johns Hopkins University School of Medicine, and Cedars-Sinai…
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New Imaging technique maps serotonin activity in Brain
Serotonin is a neurotransmitter that’s partly responsible for feelings of happiness and for mood regulation in humans. This makes it a common target for antidepressants, which block serotonin from being reabsorbed by neurons after it has dispatched its signal, so more of it stays floating around the brain. Now MIT researchers have developed an imaging…
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Scientists link single gene mutation of NF1 to some cases of autism spectrum disorder
Scientists have linked mutations in a single gene to autism in people who have a rare tumor syndrome typically diagnosed in childhood. The findings, in patients with neurofibromatosis type 1 (NF1), may lead to a better understanding of the genetic roots of autism in the wider population. The findings are published Oct. 19 in the…
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