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Neoadjuvant immunotherapy using nivolumab prior to early lung cancer surgery is safe and feasible
Adapted from Press release by European Society for Medical OncologyNeoadjuvant immunotherapy with the PD-1 inhibitor nivolumab is safe and feasible prior to surgery for early lung cancer, researchers reported at the ESMO 2016 Congress in Copenhagen. Background “Until now nivolumab and the other anti-PD-1 and anti-PD-L1 drug studies have only been reported in metastatic or…
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Data analysis using Integrated Microbial Next Generation Sequensing (IMNGS) enables worldwide bacterial analysis
Press release by Technical University of Munich Sequencing data from biological samples such as the skin, intestinal tissues, or soil and water are usually archived in public databases. This allows researchers from all over the globe to access them. However, this has led to the creation of extremely large quantities of data. To be able…
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Research shows how tumor cells evade T-cell immunotherapy
Adapted from press release by Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Berlin Institute of Health. Immunotherapy is a new and highly promising form of treatment for cancer. In many patients, however, tumors recur after immunotherapy. In the latest issue of the Journal of Experimental Medicine, the members of a…
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Reactome announces annotation and release of 10,000th human protein
Adapted from press release by Ontario Institute for Cancer Research The European Bioinformatics Institute (EMBL-EBI), the New York University School of Medicine and the Ontario Institute for Cancer Research (OICR) today announced a major milestone in the Reactome project: the annotation and release of its 10,000th human protein, making it the most comprehensive open access…
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Genes that control cellular senescence identified
Adapted from press release by Kobe University A research group including Professor Kamada Shinji, Research Fellow Nagano Taiki (both from the Kobe University Biosignal Research Center), and Unit Chief Enari Masato (National Cancer Research Institute) has succeeded in identifying genes that control cellular senescence – permanently arrested cell growth. The process involved treating liver cancer…
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Biosafety studies of Hematopoietic Stem Cell Gene Therapy for Mucopolysaccharidosis I shows promise for human trials
Extensive biosafety studies of hematopoietic stem cell (HSC) gene therapy, intended to replace a protein that patients with the inherited disease mucopolysaccaridosis I (MPS I) cannot produce, support clinical testing of the stem cell-based gene addition approach in MPS I patients. Evidence derived from these studies not only indicates that the HSC gene therapy is…
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Researchers find how Human Papilloma Virus manipulates immune system
Researchers from New Zealand’s University of Otago have gained fresh insights into how one of the main viruses that cause cervical cancer evades its hosts’ immune systems. Their findings, which are published in the international journal Scientific Reports, suggest that a protein known as E7, produced by a high-risk type of human papillomavirus (HPV16), may…
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Researchers found unique genetic basis in autism genes that may lead to earlier diagnosis
Ben-Gurion University of the Negev (BGU) researchers are a step closer to understanding the genetic basis of autism, which they hope will lead to earlier diagnosis of what is rapidly becoming the most prevalent developmental disorder worldwide. In the study published in Behavior Genetics, the researchers examined the sequences of more than 650 genes associated…
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Study demonstrates role of gut bacteria in neurodegenerative diseases
Alzheimer’s disease (AD), Parkinson’s disease (PD) and Amyotrophic Lateral Sclerosis (ALS) are all characterized by clumped, misfolded proteins and inflammation in the brain. In more than 90 percent of cases, physicians and scientists do not know what causes these processes to occur. Robert P. Friedland, M.D., the Mason C. and Mary D. Rudd Endowed Chair…
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