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Gene causing sensorineural hearing loss identified
A causative gene for a highly common type of hearing loss (sensorineural hearing loss, or SNHL) has been identified by a group of Japanese researchers, who successfully replicated the condition using a transgenic mouse. This discovery could potentially be used to develop new treatments for hearing loss. The findings were published on October 5 in…
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Improving participation in cancer screening should be a priority
Early diagnosis of cancer is linked to better survival rates. Unfortunately, participation rates for cancer screening worldwide are low even when screening programmes are free. The ESMO 2016 Congress is showcasing five studies (1) on this important area of cancer management which look at alternative ways to overcome barriers and improve screening rates Professor J-F…
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Neoadjuant PARP inhibitor treatment shrinks tumors in BRCA-positive breast cancer patients
All 13 newly diagnosed breast cancer patients with BRCA mutations had their tumors shrink significantly when treated with a PARP inhibitor ahead of frontline presurgical chemotherapy in a pilot study at The University of Texas MD Anderson Cancer Center. Results of the study (abstract 153PD) will be presented Saturday at a breast cancer poster discussion…
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Vitamin E may prevent pneumonia in nonsmoking elderly men
Administration of 50 mg per day of vitamin E decreased the risk of pneumonia in elderly male smokers by 72% after they quit smoking, according to a paper published in Clinical Interventions in Aging. Dr. Harri Hemila, University of Helsinki, Finland, studied whether vitamin E supplementation might influence the risk of community-acquired pneumonia. He analyzed…
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New Mouse Model used find potential drug target for Autism
(Philadelphia) A study of a new mouse model identifies a drug target that has the potential to increase social interaction in individuals with some forms of autism spectrum disorder (ASD), according to researchers in the Perelman School of Medicine at the University of Pennsylvania. The team published their work in Biological Psychiatry. Although medications are…
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UCLA researchers use 3-d cultures to create lung organoids
By coating tiny gel beads with lung-derived stem cells and then allowing them to self-assemble into the shapes of the air sacs found in human lungs, researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have succeeded in creating three-dimensional lung “organoids.” The laboratory-grown lung-like tissue can…
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Nanoparticle injections minimize inflammation following cartilage injury
Osteoarthritis is a debilitating condition that affects at least 27 million people in the United States, and at least 12 percent of osteoarthritis cases stem from earlier injuries. Over-the-counter painkillers, such as anti-inflammatory drugs, help reduce pain but do not stop unrelenting cartilage destruction. Consequently, pain related to the condition only gets worse. Now, researchers…
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Gene therapy for Cystic fibrosis updates
Two new studies from the University of Iowa suggest that gene therapy may be a viable approach for treating or preventing lung disease caused by cystic fibrosis (CF). Working with CF pigs, the researchers, based in the UI Pappajohn Biomedical Institute (PBI), have shown that two different virus-based vectors can restore a working version of…
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Universal Biomarker Assay To Detect Aging Cell
Scientists have developed a new, more effective method for detecting aging cells across various biological materials, promising to enhance our understanding of cellular development, aging, and disease causation. This innovative technique, detailed as a robust, universal biomarker in the journal Ageing Cell, offers significant advantages in sensitivity, specificity, and ease of use, potentially leading to…
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