Tag: Cancer
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Sybil, a machine-learning model for lung cancer risk assessment
Researchers at MIT’s Abdul Latif Jameel Clinic for Machine Learning in Health, Mass General Cancer Center, and Chang Gung Memorial Hospital have developed an artificial intelligence tool named Sybil for lung cancer risk assessment. Sybil analyzes low-dose computed tomography (LDCT) image data without using clinical or demographic data to predict a patient’s risk of developing…
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Quantum dot technology to advance molecular cell imaging
Researchers from the University of Illinois at Urbana-Champaign bioengineering team and Mayo Clinic have engineered a new type of molecular probe that can measure and count RNA in cells and tissue without organic dyes. The probe is based on the conventional fluorescence in situ hybridization (FISH) technique, but it relies on compact quantum dots to…
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Improvements in optical mammography to advance breast cancer diagnostics
Researchers from Politecnico di Milano, Italy report improvements in the design of optical mammography used in diagnosis and monitoring of breast cancer. They report increase sensitivity by a thousandfold.This research is presented at Biomedical Optics meeting 2018. Schematic diagram of new and improved optical mammography device.Credit: Edoardo Ferocino Optical mammography uses infrared light and is used…
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A new approach to create targeted nanovesicles for cancer treatment
Researchers have used autologous immune cells from the mouse to create nanovesicles to be used in the delivery of drugs to tumors. This technique helped them to create a sufficient number of nanovesicles inexpensively to be used as drug delivery system. This image shows ligands-grafted extracellular vesicles as drug delivery vehicles.Credit: Xin Zou Cells naturally…
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New targeted epigenetic therapy for lymphoma shows promise
New compounds targeting epigenetics have shown promise in treating patients with lymphoma, according to data presented at the Targeted Anticancer Therapies International Congress 2018 in Paris, France. ESMO’s phase-I oncology meeting featured early clinical studies with BET inhibitors and EZH2 inhibitors. Dr. Anastasios Stathis, head of the New Drugs Development Unit of the Oncology Institute…
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Hemanthamine found in Daffodils has anti-cancer properties
Researchers from Université Libre de Bruxelles discover that alkaloid found in Daffodils has anti-cancer properties. This alkaloid called haemanthamine works by triggering activation of anti-tumor surveillance pathway. This study was led by Dennis Lafontaine and is published in journal Structure. Structure of Ribosome. Credit ULB Researchers found that this compound binds to the ribosome and…
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Finding new uses for old medication using computer program DrugPredict
Researchers at Case Western Reserve University School of Medicine have developed a computer program called DrugPredict to discover new indications for old drugs. This program matches existing data about FDA-approved drugs to diseases, and predicts potential drug efficacy. In a recent study published in Oncogene, the researchers successfully translated DrugPredict results into the laboratory, and…
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Novel and unique DNA vaccine to fight effectively against cancer antigen
Scientists at The Wistar Institute and Inovio pharmaceuticals, Inc. have devised a unique deoxyribonucleic acid (DNA) vaccine approach through molecular design to boost the immune responses induced against one of the most important cancer antigen targets. Research results were published in the journal Molecular Therapy. Cancer immunotherapy approaches, designed to harness the body’s natural immune…
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Gene therapy using lipid based nanoparticles
Lipid nanoparticles (SLNs and NLCs) are regarded as highly promising systems for delivering nucleic acids in gene therapy. Literature review by researchers at PharmaNanoGene describes these systems and their main advantages in gene therapy, such as their capacity to protect the gene material against degradation, to facilitate cell and nucleus internalization and to boost the transfection process. View…
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