Researchers identify role of protein TOM-1 in Alzheimer’s disease pathology

The scientists from the University of California Irvine discovered that reducing the amount of protein TOM-1 in Alzheimer’s rodent models increased pathology, which included increased inflammation, and exacerbated cognitive problems associated with the disease and restoring TOM-1 levels reversed those effects.

This research is significant as it explores the molecular pathways underlying Alzheimer’s disease. It also provides information about the TOM-1 signaling pathway and its role in interleukin-1β mediated inflammation in the brain. This provides a new therapeutic target to treat Alzheimer’s disease

This animal study is published in Proceedings of the National Academy of Sciences.