Anti aging drugs focus – Rapamycin

New opinion article by Dr. Mikhail V. Blagosklonny about anti aging drug published in the journal Aging. Drug in focus is rapamycin, which functions by inhibiting mTOR pathway. Similar drugs include everolimus. Normally when over-activated by nutrients and insulin, mTOR acts via S6K to inhibit insulin signaling, thereby causing insulin resistance. The evidence in preclinical … Continue reading Anti aging drugs focus – Rapamycin

Researchers identify role of protein TOM-1 in Alzheimer’s disease pathology

The scientists from the University of California Irvine discovered that reducing the amount of protein TOM-1 in Alzheimer's rodent models increased pathology, which included increased inflammation, and exacerbated cognitive problems associated with the disease and restoring TOM-1 levels reversed those effects. This research is significant as it explores the molecular pathways underlying Alzheimer's disease. It … Continue reading Researchers identify role of protein TOM-1 in Alzheimer’s disease pathology